CAS No.: 58-14-0
乙嘧啶 Catalog No. CSN12806
Synonyms: 乙胺嘧啶;Pirimecidan;Pirimetamin
Pyrimethamine inhibits multidrug and toxin extrusion (MATE) transporter potently, it also inhibits dihydrofolate reductase (DHFR), used for protozoal infections and interferes with tetrahydrofolic acid synthesis from folic acid. Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00164710 Malaria, Falciparum Phase 4 Completed - Malawi ... more >> Kawale Health Center Lilongwe, Lilongwe District, Malawi Machinga District Hospital Liwonde, Machinga District, Malawi Matiki Health Center Dwangwa, Nkhotakota District, Malawi Collapse << NCT00711906 Malaria in Pregnancy Phase 3 Terminated(Malaria prev. fell ... more >>in the study area, so we cannot evaluate the primary endpoint) Collapse << - Zambia ... more >> Choma hospital Choma, Zambia Shampande Clinic Shampande, Zambia Collapse << NCT01084213 Malaria Pregn... more >>ancy Anaemia Collapse << Phase 4 Completed - Burkina Faso ... more >> Université de Ouagadougou Ouagadougou, Burkina Faso Gambia Medical Research Council Laboratories Basse, Gambia Ghana Navrongo Health Research Centre Navrongo, Ghana Mali Medical Research and Training Centre Bamako, Mali Collapse << - 更多
- 参考文献
- [1] Maegawa GH, Tropak M, et al. Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. J Biol Chem. 2007 Mar 23;282(12):9150-61.
- [2] Akao M, Teshima Y, Marban E. Antiapoptotic effect of nicorandil mediated by mitochondrial atp-sensitive potassium channels in cultured cardiac myocytes. J Am Coll Cardiol. 2002 Aug 21;40(4):803-10.
- [3] Basco LK, Ramiliarisoa O, Le Bras J. In vitro activity of pyrimethamine, cycloguanil, and other antimalarial drugs against African isolates and clones of Plasmodium falciparum. Am J Trop Med Hyg. 1994 Feb;50(2):193-9
- [4] Wright PD, Huang M, Weiss A, Matthews J, Wightman N, Glicksman M, Brown RH Jr. Screening for inhibitors of the SOD1 gene promoter: pyrimethamine does not reduce SOD1 levels in cell and animal models. Neurosci Lett. 2010 Oct 4;482(3):188-92
- [5] Martins-Duarte ÉS, de Souza W, Vommaro RC. Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model. Exp Parasitol. 2013 Mar;133(3):294-9
- [6] Taylor WR, White NJ. Antimalarial drug toxicity: a review. Drug Saf. 2004;27(1):25-61
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 58-14-0 | 储存条件 |
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| 分子式 | C12H13ClN4 | 运输 | 蓝冰 | |||||||
| 分子量 | 248.71 | 别名 | 乙胺嘧啶;Pirimecidan;Pirimetamin;RP 4753 | |||||||
| 溶解度 |
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动物实验配方 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT00164710 | Malaria, Falciparum | Phase 4 | Completed | - | Malawi ... more >> Kawale Health Center Lilongwe, Lilongwe District, Malawi Machinga District Hospital Liwonde, Machinga District, Malawi Matiki Health Center Dwangwa, Nkhotakota District, Malawi Collapse << |
| NCT00711906 | Malaria in Pregnancy | Phase 3 | Terminated(Malaria prev. fell ... more >>in the study area, so we cannot evaluate the primary endpoint) Collapse << | - | Zambia ... more >> Choma hospital Choma, Zambia Shampande Clinic Shampande, Zambia Collapse << |
| NCT01084213 | Malaria Pregn... more >>ancy Anaemia Collapse << | Phase 4 | Completed | - | Burkina Faso ... more >> Université de Ouagadougou Ouagadougou, Burkina Faso Gambia Medical Research Council Laboratories Basse, Gambia Ghana Navrongo Health Research Centre Navrongo, Ghana Mali Medical Research and Training Centre Bamako, Mali Collapse << |
| NCT00203736 | Malaria | Not Applicable | Completed | - | Mozambique ... more >> Catuane Clinic Catuane, Matutuine, Mozambique Namaacha Clinic Namaacha, Mozambique Collapse << |
| NCT00209781 | Pregnancy | Not Applicable | Unknown | - | Mozambique ... more >> Centro de Investigaçao em Saude da Manhiça Manhiça, Maputo, Mozambique Collapse << |
| NCT00367081 | Toxoplasmic Encephalitis ... more >> AIDS Collapse << | Phase 4 | Completed | - | Thailand ... more >> Chiang Mai University hospital (2003-2004) Chiang Mai, Thailand, 50200 Collapse << |
| NCT01443130 | Malaria | Phase 3 | Completed | - | Malawi ... more >> Blantyre Malaria Project - Queen Elizabeth Central Hospital Blantryre, Blantyre, Malawi Collapse << |
| NCT00372294 | Chorioretinitis | Phase 3 | Unknown | November 2008 | Iran, Islamic Republic of ... more >> Ophthalmic Research Center Tehran, Iran, Islamic Republic of, 16666 Collapse << |
| NCT03035305 | Malaria | Not Applicable | Completed | - | Mali ... more >> Amcp/Alima Kolokani Circle, Koulikoro region, Mali Collapse << |
| NCT01443130 | - | - | Completed | - | - |
| NCT00001994 | Toxoplasmosis, Cerebral ... more >> HIV Infections Collapse << | Not Applicable | Completed | - | United States, California ... more >> Los Angeles County - USC Med Ctr Los Angeles, California, United States, 90033 Infectious Disease Med Group Oakland, California, United States, 94609 San Francisco Gen Hosp San Francisco, California, United States, 941102859 UCSF - San Francisco Gen Hosp San Francisco, California, United States, 94110 Davies Med Ctr San Francisco, California, United States, 94114 United States, District of Columbia Georgetown Univ Med Ctr Washington, District of Columbia, United States, 20007 United States, Georgia Infectious Disease Research Consortium of Georgia Atlanta, Georgia, United States, 30345 United States, Maryland Johns Hopkins Hosp Baltimore, Maryland, United States, 21205 United States, New York Beth Israel Med Ctr New York, New York, United States, 10003 Saint Vincent's Hosp and Med Ctr New York, New York, United States, 10011 Harlem Hosp Ctr New York, New York, United States, 10037 SUNY / Health Sciences Ctr at Stony Brook Stony Brook, New York, United States, 117948153 United States, North Carolina Duke Univ Med Ctr Durham, North Carolina, United States, 27710 United States, Oregon Portland Veterans Adm Med Ctr / Rsch & Education Grp Portland, Oregon, United States, 97210 United States, Tennessee Regional Med Ctr at Memphis Memphis, Tennessee, United States, 38103 United States, Texas Gathe, Joseph, M.D. Houston, Texas, United States, 77004 Baylor College of Medicine Houston, Texas, United States, 77030 United States, Virginia Infectious Disease Physicians Inc Annandale, Virginia, United States, 22203 Canada, Alberta Southern Alberta HIV Clinic / Foothills Hosp Calgary, Alberta, Canada Canada, British Columbia Dr Julio S G Montaner Vancouver, British Columbia, Canada Canada, Ontario Wellesley Hosp Toronto, Ontario, Canada Canada, Quebec Dr Emil Toma / Hotel Dieu de Montreal Montreal, Quebec, Canada Collapse << |
| NCT02793622 | Malaria | Phase 3 | Active, not recruiting | June 2019 | Uganda ... more >> IDRC - Tororo Research Clinic Tororo, Uganda Collapse << |
| NCT02575755 | Pregnancy Inf... more >>ections, Plasmodia Drug Kinetics Clinical Efficacy Collapse << | Phase 4 | Unknown | October 2016 | Papua New Guinea ... more >> Papua New Guinea Institute of Medical Research Recruiting Madang, Madang Province, Papua New Guinea, 511 Contact: Brioni R Moore, BSc, PhD (+61) 0466266334 brioni.moore@uwa.edu.au Contact: Leanne J Robinson, BSc, PhD, MPH (+675) 422 2909 robinson@wehi.edu.au Collapse << |
| NCT00948896 | Malaria | Phase 3 | Completed | - | Uganda ... more >> IDRC Research Clinic -Tororo District Hospital Tororo, Uganda Collapse << |
| NCT00712374 | Malaria | Phase 4 | Unknown | July 2012 | - |
| NCT00529620 | Malaria | Phase 3 | Completed | - | Senegal ... more >> Departement de Parasitologie et Mycologie, Universite Cheikh Anta Diop Dakar, Senegal Collapse << |
| NCT03208179 | Pregnancy Mal... more >>aria in Pregnancy Malaria Collapse << | Phase 3 | Not yet recruiting | October 2019 | Kenya ... more >> Ahero Sud-countyHospital Not yet recruiting Ahero, Kisumu, Kenya Contact: Simon Kariuki, PhD + 254725389246 SKariuki@kemricdc.org Homa Bay County Hospital Not yet recruiting Homa Bay, Kenya Contact: Simon Kariuki, PhD + 254725389246 SKariuki@kemricdc.org Rabour Sub-county Hospital Not yet recruiting Kisumu, Kenya Contact: Simon Kariuki, PhD + 254725389246 SKariuki@kemricdc.org Malawi Chikwawa District Hospital Not yet recruiting Chikwawa, Malawi Contact: Victor Mwapasa, PhD +265999981496 vmwapasa@gmail.com Mangochi District Hospital Not yet recruiting Mangochi, Malawi Contact: Kenneth Maleta, PhD +265888232202 ken.maleta@gmail.com Tanzania Handeni District Hospital Handeni, Tanzania Korogwe District Hospital Korogwe, Tanzania Collapse << |
| NCT00948896 | - | - | Completed | - | - |
| NCT00168948 | Malaria Anemi... more >>a Collapse << | Phase 4 | Unknown | - | - |
| NCT00119132 | Malaria | Phase 2 Phase 3 | Completed | - | Ghana ... more >> Ministry of Health, Hohoe district hospital Hohoe, Volta region, Ghana Collapse << |
| NCT00510159 | Schistosoma Haematobium | Phase 2 Phase 3 | Completed | - | Mali ... more >> Djalakorodji, Mali Collapse << |
| NCT01255605 | - | - | Completed | - | Burkina Faso ... more >> Institut Supérieur des Sciences de la Santé/Université Polytechnique de Bobo-Dioulasso Bobo-Dioulasso, Houet, Burkina Faso, 1091 Collapse << |
| NCT00460369 | Uncomplicated Malaria | Not Applicable | Completed | - | Benin ... more >> Centre de santé Allada, Benin Collapse << |
| NCT00304980 | Plasmodium Falciparum Malaria | Not Applicable | Terminated | - | Zambia ... more >> Tropical Disease Research Center Ndola, Cupperbelt, Zambia Collapse << |
| NCT00203801 | Malaria | Not Applicable | Completed | - | Mozambique ... more >> Bela Vista Clinic Bela Vista, Matutuine, Mozambique Namaacha Clinic Namaacha, Mozambique South Africa Ndumo Clinic Ndumo, KwaZulu Natal, South Africa Lulekani Clinic Lulekani, Limpopo, South Africa Naas Clinic Naas, Mpumalanga, South Africa Swaziland Ndzevane Clinic Ndzevane, Swaziland Vuvulane Clinic Vuvulane, Swaziland Collapse << |
| NCT00158574 | Malaria | Phase 2 Phase 3 | Completed | - | Tanzania ... more >> Ministry of Health, Korogwe and Same District MCH clinics Tanga, Tanga and Kilimanjaro, Tanzania Collapse << |
| NCT00330902 | Plasmodium Infections | Phase 3 | Completed | - | Sudan ... more >> Tropical Medicine Research Institute Khartoum, Sudan Collapse << |
| NCT00158561 | Malaria Vivax... more >> Malaria Collapse << | Phase 3 | Completed | - | Pakistan ... more >> HealthNet International Peshawar, Pakistan Collapse << |
| NCT00766662 | Malaria | Not Applicable | Completed | - | Mali ... more >> Malaria Research & Training Center; Faculty of Medicine, Pharmacy and Dentistry, University of Bamako Bamako, Mali, 0000 Collapse << |
| NCT00132561 | Malaria | Phase 2 Phase 3 | Completed | - | Senegal ... more >> Institut de recherche pour le developpement Dakar, Senegal, BP 1386 Collapse << |
| NCT02909712 | Malaria Pregn... more >>ancy Cardiotoxicity Parasitemia Collapse << | Phase 2 | Unknown | September 2017 | Tanzania ... more >> Handeni District Hospital Recruiting Handeni, Tanga Region, Tanzania Contact: George Mtove Collapse << |
| NCT00270530 | Placental Malaria Infection ... more >> HIV Infections Stillbirth Prematurity Neonatal Deaths Collapse << | Phase 4 | Completed | - | Zambia ... more >> Tropical Diseases Research Centre Ndola, Zambia Collapse << |
| NCT00158548 | Malaria Falci... more >>parum Malaria Vivax Malaria Collapse << | Phase 3 | Completed | - | Pakistan ... more >> HealthNet International Peshawar, Pakistan Collapse << |
| NCT01319448 | Malaria Sickl... more >>e Cell Crisis Collapse << | Phase 1 Phase 2 | Completed | - | Nigeria ... more >> Department of Paediatrics and Child Health, University of Ilorin Teaching Hospital Ilorin, Kwara, Nigeria Collapse << |
| NCT00274235 | Malaria | Phase 3 | Completed | - | Benin ... more >> Institut de Recherche pour le Développement Cotonou, Benin, 01 BP 4414 RP Collapse << |
| NCT00164255 | Malaria | Phase 4 | Completed | - | Tanzania ... more >> Kibaoni Health Centre Ifakara, Kilombero District, Tanzania St Francis Designated District Hospital Ifakara, Kilombero District, Tanzania Collapse << |
| NCT00146783 | Malaria | Phase 2 Phase 3 | Completed | - | Ghana ... more >> Navrongo District Hosptial Navrongo, Upper East Region, Ghana Collapse << |
| NCT01746199 | Malaria in Pregnancy ... more >> HIV Infection Collapse << | Phase 3 | Unknown | - | Central African Republic ... more >> Maternité de l'Hôpital communautaire Not yet recruiting Bangui, Central African Republic Maternité de l'Hôpital de l'Amitié Not yet recruiting Bangui, Central African Republic Maternité de la Gendarmerie Nationale Not yet recruiting Bangui, Central African Republic Maternité du centre de santé des Castors Not yet recruiting Bangui, Central African Republic Collapse << |
| NCT00372632 | Non HIV Infected Pregnant Wome... more >>n Collapse << | Phase 4 | Completed | - | Rwanda ... more >> Programme Nationale de Controle de Paludisms Kigali, Rwanda Collapse << |
| NCT00131716 | Anemia | Phase 3 | Completed | - | Gambia ... more >> Medical Research Council Laboratories, Banjul, Gambia Collapse << |
| NCT00167843 | Malaria | Phase 4 | Completed | - | Gabon ... more >> Medical Research Unit of the Albert Schweitzer Hospital Lambaréné, Moyen Ogooué, Gabon, B.P. 118 Collapse << |
| NCT00203814 | Malaria | Not Applicable | Completed | - | Mozambique ... more >> Boane Clinic Boane, Maputo, Mozambique Magude Clinic Magude, Mozambique Collapse << |
| NCT00361114 | Malaria | Phase 3 | Terminated(SP arms were stoppe... more >>d due to high levels of treatment failure.CD not available.) Collapse << | - | Tanzania ... more >> Hale Dispensary Korogwe, Tanga Region, Tanzania Collapse << |
| NCT00120822 | Malaria | Phase 3 | Completed | - | Gambia ... more >> Medical Research Council, Laboratories Banjul, Gambia, PO Box 273 Collapse << |
| NCT03009526 | Malaria Pregn... more >>ancy Collapse << | Phase 3 | Active, not recruiting | December 31, 2018 | Malawi ... more >> Malaria Alert Center, University of Malawi College of Medicine Liwonde, Malawi Collapse << |
| NCT03525730 | HIV-1-infection | Phase 1 Phase 2 | Recruiting | April 2020 | Netherlands ... more >> Erasmus MC Recruiting Rotterdam, Netherlands, 3015 CN Contact: Casper Rokx, MD PhD +31681336328 c.rokx@erasmusmc.nl Sub-Investigator: Henrieke Prins, MD Sub-Investigator: Jeroen van Kampen, MD PhD Sub-Investigator: Yvonne Muller, PhD Sub-Investigator: Tokameh Mahmoudi, PhD Sub-Investigator: Charles Boucher, MD PhD Sub-Investigator: Annelies Verbon, MD PhD Sub-Investigator: David Burger, PHD Collapse << |
| NCT02211729 | Malaria Respi... more >>ratory Infections Collapse << | Phase 3 | Completed | - | Burkina Faso ... more >> Hounde district Hospital Hounde, Burkina Faso Mali Bougouni Koulikoro District hospital Bougouni, Mali Collapse << |
| NCT01669941 | Pregnancy Mal... more >>aria Collapse << | Phase 4 | Completed | - | Kenya ... more >> Lwak Mission Hospital Rarieda, Nyanza, Kenya Siaya District Hospital Siaya, Nyanza, Kenya, 40600 Bondo District Hospital Bondo, Kenya, 40601 Madiany sub-District Hospital Madiany, Kenya Collapse << |
| NCT01636895 | Pregnancy Complications Parasi... more >>tic Collapse << | Phase 4 | Unknown | February 2013 | Nigeria ... more >> Damboa Hospital Borno state and Park Lane hospital Enugu state Recruiting Enugu,, borno State and Enugu state, Nigeria Contact: Elvis N Shu Cell: + 234 803 317 0257 shuneba@gmail.com Principal Investigator: Elvis Shu Collapse << |
| NCT00131703 | Malaria Pregn... more >>ancy Collapse << | Phase 3 | Completed | - | - |
| NCT00000674 | Toxoplasmosis, Cerebral ... more >> HIV Infections Collapse << | Not Applicable | Completed | - | United States, California ... more >> USC CRS Los Angeles, California, United States, 90033 Stanford CRS Palo Alto, California, United States, 94304 Ucsd, Avrc Crs San Diego, California, United States, 92103 United States, Florida Univ. of Miami AIDS CRS Miami, Florida, United States, 33136 United States, Maryland Johns Hopkins Adult AIDS CRS Baltimore, Maryland, United States, 21287 United States, Missouri Washington U CRS St. Louis, Missouri, United States United States, New York SUNY - Buffalo, Erie County Medical Ctr. Buffalo, New York, United States, 14215 NY Univ. HIV/AIDS CRS New York, New York, United States, 10016 Cornell University A2201 New York, New York, United States, 10021 Memorial Sloan-Kettering Cancer Ctr. New York, New York, United States, 10021 United States, North Carolina Unc Aids Crs Chapel Hill, North Carolina, United States, 27599 Duke Univ. Med. Ctr. Adult CRS Durham, North Carolina, United States, 27710 United States, Pennsylvania Pitt CRS Pittsburgh, Pennsylvania, United States, 15213 Collapse << |
| NCT03640403 | Malaria,Falciparum ... more >> Anemia Collapse << | Phase 4 | Not yet recruiting | December 2021 | Tanzania ... more >> National Institute for Medical Research Not yet recruiting Tanga, Tanzania, 255 Contact: Centre Director +255272646084 tanga@nimr.or.tz Contact: Vito Baraka, PhD +255715380010 vitobaraka@gmail.com Principal Investigator: Geofrey Makenga, MD, MSc Sub-Investigator: Vito Baraka, PhD Sub-Investigator: Filbert Fransis, MSc Sub-Investigator: Rashid Madebe, MSc Sub-Investigator: Edwin Liheluka, MSc Collapse << |
| NCT00084240 | Malaria, Falciparum | Phase 2 Phase 3 | Terminated(See Detailed Descri... more >>ption) Collapse << | - | - |
| NCT00004317 | Toxoplasmosis | Phase 4 | Recruiting | December 2030 | United States, Illinois ... more >> University of Chicago Recruiting Chicago, Illinois, United States, 60637 Contact: Rima McLeod 773-834-4152 Collapse << |
| NCT00000966 | Toxoplasmosis, Cerebral ... more >> HIV Infections Collapse << | Phase 1 | Completed | - | United States, California ... more >> Los Angeles County - USC Med Ctr Los Angeles, California, United States, 90033 United States, Florida Univ of Miami School of Medicine Miami, Florida, United States, 331361013 United States, Massachusetts Univ of Massachusetts Med Ctr Worcester, Massachusetts, United States, 01655 United States, New York Bronx Municipal Hosp Ctr/Jacobi Med Ctr Bronx, New York, United States, 10461 Montefiore Med Ctr / Bronx Municipal Hosp Bronx, New York, United States, 10467 Bronx Veterans Administration / Mount Sinai Hosp Bronx, New York, United States, 10468 Nassau County Med Ctr East Meadow, New York, United States, 11554 Bellevue Hosp / New York Univ Med Ctr New York, New York, United States, 10016 Cornell Univ Med Ctr New York, New York, United States, 10021 SUNY - Stony Brook Stony Brook, New York, United States, 117948153 United States, South Carolina Julio Arroyo West Columbia, South Carolina, United States, 29169 Collapse << |
| NCT00074841 | PLASMODIUM FALCIPARUM MALARIA | Phase 2 Phase 3 | Completed | - | India ... more >> Pfizer Investigational Site Dispur Guwahati, Assam, India, 781006 Pfizer Investigational Site Bambolim, Gao, India, 403002 Pfizer Investigational Site Nagpur, Maharashtra, India, 440 018 Pfizer Investigational Site Parel Mumbai, Maharashtra, India, 400012 Pfizer Investigational Site Rourkela, Orissa, India, 769005 Pfizer Investigational Site Vellore, Tamil Nadu, India, 632 004 Pfizer Investigational Site Indore, India, 452001 Collapse << |
| NCT00000973 | Toxoplasmosis, Cerebral ... more >> HIV Infections Collapse << | Phase 1 | Completed | - | United States, New York ... more >> Memorial Sloan-Kettering Cancer Ctr. New York, New York, United States, 10021 United States, North Carolina Unc Aids Crs Chapel Hill, North Carolina, United States, 27599 Collapse << |
| NCT00000794 | Toxoplasmosis, Cerebral ... more >> HIV Infections Collapse << | Phase 2 | Completed | - | United States, California ... more >> USC CRS Los Angeles, California, United States, 900331079 United States, Florida Univ. of Miami AIDS CRS Miami, Florida, United States, 331361013 United States, Hawaii Queens Med. Ctr. Honolulu, Hawaii, United States, 96816 Univ. of Hawaii at Manoa, Leahi Hosp. Honolulu, Hawaii, United States, 96816 United States, Illinois Northwestern University CRS Chicago, Illinois, United States, 60611 Cook County Hosp. CORE Ctr. Chicago, Illinois, United States, 60612 United States, Indiana Indiana Univ. School of Medicine, Infectious Disease Research Clinic Indianapolis, Indiana, United States, 462025250 Methodist Hosp. of Indiana Indianapolis, Indiana, United States, 46202 United States, Maryland Johns Hopkins Adult AIDS CRS Baltimore, Maryland, United States, 21287 United States, Missouri Washington U CRS St. Louis, Missouri, United States, 63110 St. Louis ConnectCare, Infectious Diseases Clinic St. Louis, Missouri, United States United States, New York SUNY - Buffalo, Erie County Medical Ctr. Buffalo, New York, United States, 13210 Beth Israel Med. Ctr. (Mt. Sinai) New York, New York, United States, 10003 NY Univ. HIV/AIDS CRS New York, New York, United States United States, Ohio Univ. of Cincinnati CRS Cincinnati, Ohio, United States, 452670405 The Ohio State Univ. AIDS CRS Columbus, Ohio, United States, 432101228 Collapse << |
| NCT01722539 | Healthy | Phase 3 | Completed | - | Congo ... more >> Mokali health area of Biyela health zone, in Kinshasa province. Kinshasa, Kinshasa province, Congo Collapse << |
| NCT00013689 | Autoimmune Disease ... more >> Lymphoproliferative Disorder Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> National Institute of Allergy and Infectious Diseases (NIAID) Bethesda, Maryland, United States, 20892 Collapse << |
| NCT00140361 | Malaria (Uncomplicated) | Phase 4 | Completed | - | Tanzania ... more >> Ngere Ngere Health Center Ngere Ngere, Morogoro Rural, Tanzania Ikwiriri Health Center Ikwiriri, Rufiji, Tanzania Lupiro Health Center Lupiro, Ulanga, Tanzania Collapse << |
| NCT00229775 | Malaria | Not Applicable | Completed | - | Philippines ... more >> Kalinga Health Center Tabuk, Kalinga Province, Philippines Davao Health Center Davao City, Mindinao, Philippines Palawan Health Center Puerto Princesa, Palawan, Philippines Collapse << |
| NCT00126906 | Malaria, Falciparum ... more >> HIV Infections Collapse << | Not Applicable | Completed | - | Malawi ... more >> Machinga District Hospital Liwonde, Malawi Collapse << |
| NCT02511054 | Malaria | Phase 1 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
| NCT01103063 | Intermittent Preventive Treatm... more >>ent In Pregnancy (IPTp) Collapse << | Phase 3 | Terminated(See termination rea... more >>son in detailed description.) Collapse << | - | Benin ... more >> Centre de Santé d'AHOUANSORI-AGUE Cotonou, Benin Hôpital Bethesda Cotonou, Benin Kenya Siaya District Hospital Siaya, Kenya Malawi Zomba Central Hospital Zomba, Malawi Tanzania Teule Hospital Muheza, Tanga, Tanzania Bugando Medical Centre Mwanza, Tanzania, 1903 Nyamagana District Hospital, c/o National Institute for Medical Research, Mwanza Centre Mwanza, Tanzania Nyamagana District Hospital Mwanza, Tanzania Uganda Mulago Hospital Complex Kampala, Uganda Collapse << |
| NCT00964691 | Malaria Malar... more >>ia in Pregnancy Collapse << | Phase 4 | Terminated(Low prevalence of m... more >>alaria, high prevalence of reported allergy to sulphur drugs, high proportion of women not meeting the inclusion criterea.) Collapse << | August 2010 | Solomon Islands ... more >> Honiara City Council Honiara, Solomon Islands Collapse << |
| NCT00486694 | Malaria, Vivax | Phase 2 | Completed | - | - |
| NCT00130065 | Malaria | Phase 4 | Completed | - | Kenya ... more >> CDC/Kenya Medical Research Institute Kisumu, Kenya Collapse << |
| NCT01103063 | - | - | Terminated(See termination rea... more >>son in detailed description.) Collapse << | - | - |
| NCT00137553 | Malaria, Falciparum | Phase 4 | Completed | - | Guinea-Bissau ... more >> Bandim Health Project Apartado 861, Bissau, Guinea-Bissau Collapse << |
| NCT02758353 | Malaria Still... more >>births Collapse << | Not Applicable | Completed | - | - |
| NCT01707199 | Uncomplicated P. Falciparum Ma... more >>laria Collapse << | Not Applicable | Unknown | December 2013 | Afghanistan ... more >> Narang, Asadabad, Watapoor district health centres Recruiting Kunar, Afghanistan Contact: Ghulam Rahim Awab, MD awabgr@yahoo.com Principal Investigator: Ghulam Rahim Awab, MD Collapse << |
| NCT00125489 | Malaria Plasm... more >>odium Falciparum Malaria Collapse << | Phase 4 | Completed | - | Malawi ... more >> Blantyre Malaria Project Blantyre, Malawi Collapse << |
| NCT00000666 | Toxoplasmosis, Cerebral ... more >> HIV Infections Collapse << | Not Applicable | Completed | - | United States, California ... more >> Community Consortium of San Francisco San Francisco, California, United States, 94110 United States, Colorado Denver CPCRA / Denver Public Hlth Denver, Colorado, United States, 802044507 United States, Connecticut Hill Health Corp New Haven, Connecticut, United States, 06519 United States, Delaware Wilmington Hosp / Med Ctr of Delaware Wilmington, Delaware, United States, 19899 United States, Georgia AIDS Research Consortium of Atlanta Atlanta, Georgia, United States, 30308 United States, Illinois AIDS Research Alliance - Chicago Chicago, Illinois, United States, 60657 United States, Louisiana Louisiana Comm AIDS Rsch Prog / Tulane Univ Med New Orleans, Louisiana, United States, 70112 United States, Michigan Comprehensive AIDS Alliance of Detroit Detroit, Michigan, United States, 48201 Henry Ford Hosp Detroit, Michigan, United States, 48202 United States, New Jersey North Jersey Community Research Initiative Newark, New Jersey, United States, 071032842 United States, New York Bronx Lebanon Hosp Ctr Bronx, New York, United States, 10456 Addiction Research and Treatment Corp Brooklyn, New York, United States, 11201 Clinical Directors Network of Region II New York, New York, United States, 10011 Harlem AIDS Treatment Group / Harlem Hosp Ctr New York, New York, United States, 10037 United States, Oregon Portland Veterans Adm Med Ctr / Rsch & Education Grp Portland, Oregon, United States, 972109951 United States, Virginia Richmond AIDS Consortium Richmond, Virginia, United States, 23298 Collapse << |
| NCT00167739 | Malaria | Phase 4 | Completed | - | Gabon ... more >> Medical Research Unit, Lambaréné Lambaréné, Moyen Ogooué, Gabon, B.P. 118 Collapse << |
| NCT01136850 | Malaria in Pregnancy ... more >> Sexually Transmitted Infections Anaemia Collapse << | Phase 3 | Completed | - | Papua New Guinea ... more >> Papua New Guinea Institute of Medical Research Madang, Madang Province, Papua New Guinea Collapse << |
| NCT00131235 | Malaria Sexua... more >>lly Transmitted Diseases Preterm Birth Pregnancy Collapse << | Phase 3 | Completed | - | Malawi ... more >> College of Medicine, University of Malawi Mangochi, Mangochi District, Malawi Collapse << |
| NCT00065390 | Autoimmune Disease ... more >> Lymphatic Disease Lymphoproliferative Disorder Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> National Institute of Allergy and Infectious Diseases (NIAID) Bethesda, Maryland, United States, 20892 Collapse << |
| NCT02524444 | Malaria in Pregnant HIV + Pati... more >>ents Collapse << | Phase 1 | Completed | - | Nigeria ... more >> University College Hospital Ibadan, OYO State, Nigeria, 200001 Collapse << |
| NCT03083847 | Malaria | Phase 1 | Recruiting | June 30, 2019 | United States, Maryland ... more >> National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov Collapse << |
| NCT00453856 | Malaria | Phase 4 | Terminated(The study was termi... more >>nated because of Early Treatment Failure in child.The justification for this decision are concerns about safety of children.) Collapse << | - | Gabon ... more >> Medical Research Unit of the Albert Schweitzer Hospital Lambaréné, Moyen Ogooué, Gabon, B.P. 118 Collapse << |
| NCT00120809 | Malaria | Phase 3 | Completed | - | Gambia ... more >> Medical Research Council Laboratories Banjul, Gambia, PO Box 273 Collapse << |
| NCT02527005 | Malaria Pregn... more >>ant HIV Collapse << | Phase 1 | Completed | - | Nigeria ... more >> University College Hospital, Ibadan, Oyo, Nigeria, 200001 Collapse << |
| NCT01054651 | Schistosoma Mansoni | Phase 3 | Completed | - | Kenya ... more >> KEMRI Centre for Global Health Research Kisumu, Kenya Collapse << |
| NCT01115439 | - | - | Completed | - | Afghanistan ... more >> Provincial Malaria Control Centers (MRC) Maimana, Faryab, Afghanistan Provincial Malaria Control Centers (MRC) Asadabad, Kunar, Afghanistan Provincial Malaria Control Centers (MRC) Jalalabad, Nangarhar, Afghanistan Provincial Malaria Control Centers (MRC) Taloqan, Afghanistan Collapse << |
| NCT00399074 | Sickle Cell Anemia ... more >> Malaria Collapse << | Phase 3 | Completed | - | Uganda ... more >> Mulago Hospital Kampala, Central, Uganda, 256 Collapse << |
| NCT00623155 | Malaria | Not Applicable | Completed | - | Mali ... more >> Malaria Research and Training Center, Faculty of Medicine Pharmacy and Dentistry, University of Bamako Bamako, Mali Collapse << |
| NCT00380146 | Malaria | Not Applicable | Completed | - | Mozambique ... more >> Ndlavela Health Centre Ndlavela, Maputo, Mozambique Collapse << |
| NCT00331708 | Malaria | Not Applicable | Terminated(Lack of suitable pa... more >>rticipants) Collapse << | - | Mozambique ... more >> Ndlavela Health Centre Ndlavela, Maputo, Mozambique Collapse << |
| NCT01184911 | Intermittent Preventive Treatm... more >>ent Placental Malaria Collapse << | Phase 4 | Withdrawn(Research plan change... more >>d; no longer conducting clinical trial.) Collapse << | September 2011 | Uganda ... more >> Infectious Disease Research Center Tororo, Uganda Collapse << |
| NCT00679744 | G(M2) Ganglioside ... more >> Tay-Sachs Disease Ganglioside Sandhoff Disease Ganglioside Collapse << | Phase 1 | Withdrawn(Due to lack of fundi... more >>ng) Collapse << | - | United States, New York ... more >> New York University, School of Medicine, Department of Neurology New York, New York, United States, 10016 United States, Ohio University Hospitals of Cleveland Cleveland, Ohio, United States, 44106 Canada, Ontario Division of Clinical & Metabolic Genetics, Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 Collapse << |
| NCT01328990 | Malaria | Phase 1 Phase 2 | Completed | - | Senegal ... more >> Universite Chiekh Anta Diop Dakar, Senegal Collapse << |
| NCT01083667 | Familial Amyotrophic Lateral S... more >>clerosis Collapse << | Phase 1 Phase 2 | Completed | - | United States, New York ... more >> Weill Cornell Medical Center/New York Presbyterian Hospital New York, New York, United States, 10021 United States, Texas Methodist Neurological Institute Houston, Texas, United States, 77030 Germany Universitäts- und Rehabilitationskliniken Ulm Ulm, Germany Italy Milano Neurological Institute Milan, Italy Sweden Umea University Umea, Sweden Collapse << |
| NCT01189448 | Congenital Toxoplasmosis | Phase 3 | Completed | - | France ... more >> Hôpital Louis Mourier Colombes, Hauts-de-Saine, France, 92700 Collapse << |
| NCT00951106 | Malaria, Vivax ... more >> Malaria, Falciparum Collapse << | Not Applicable | Completed | - | Peru ... more >> Naval Medical Research Center Detachment Lima, Peru Collapse << |
| NCT01083667 | - | - | Completed | - | - |
| NCT01066663 | Chronic Lymphocytic Leukemia ... more >> Small Lymphocytic Leukemia Collapse << | Phase 1 Phase 2 | Recruiting | February 2022 | United States, Massachusetts ... more >> Beth Israel Deaconess Medical Center Recruiting Boston, Massachusetts, United States, 02115 Principal Investigator: Robin Joyce, MD Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02115 Principal Investigator: Jennifer Brown, MD, PhD Collapse << |
| NCT03258762 | Toxoplasmosis | Phase 1 | Completed | - | Australia, Victoria ... more >> GSK Investigational Site Melbourne, Victoria, Australia, 3004 Collapse << |
| NCT01973933 | Healthy | Phase 1 | Completed | - | Korea, Republic of ... more >> Seoul National University Bundang Hospital Seoul, Korea, Republic of Collapse << |
| NCT01120145 | - | - | Completed | - | Malawi ... more >> Machinga District Hospital Liwonde, Machinga District, Malawi Collapse << |
| NCT03599596 | Malaria | Phase 1 | Not yet recruiting | February 1, 2019 | - |
| NCT03057990 | Myelodysplastic Syndromes | Phase 1 | Not yet recruiting | June 2020 | - |
| NCT01102686 | Gangliosidoses, GM2 ... more >> Sandhoff Disease Tay-Sachs Disease Collapse << | Phase 1 Phase 2 | Completed | - | Canada, Ontario ... more >> The Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 Collapse << |
| NCT00206739 | Malaria Anemi... more >>a Collapse << | Phase 4 | Completed | - | Ghana ... more >> Kumasi Centre for Collaborative Research in Tropical Medicine Kumasi, Ashanti Region, Ghana Collapse << |
| 靶点 | Description | IC50 |
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