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CAS No.: 61718-80-7

5-Methoxy-1-(4-(trifluoromethyl)phenyl)pentan-1-one Catalog No. CSN11680

Synonyms: Fluvoxketone

Fluvoxketone is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.

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纯度 & 质量文件批次:

靶点选择性

生物活性

描述Fluvoxketone is trifluoromethyl-substituted aryl ketone compound useful as an intermediate in the synthesis of Fluvoxamine, which is a selective serotonin reuptake inhibitor. In the synthesis of Fluvoxamine, the ketone carbonyl of Fluvoxketone is elaborated to an oxime. In vitro，the inhibitory effect of fluvoxamine on actin polymerization was concentration dependent, and its IC50 was approximately 30 μM^[3].In vivo，fluvoxamine treated EAE rats showed a decrease in IFN-γ serum levels and an increase in IL-4, pro- and anti-inflammatory cytokines respectively^[4].
参考文献

[1] Altria KD, McLean R. Development and optimisation of a generic micellar electrokinetic capillary chromatography method to support analysis of a wide range of pharmaceuticals and excipients. J Pharm Biomed Anal. 1998 Dec;18(4-5):807-13.
[2] Terabe S. Selectivity manipulation in micellar electrokinetic chromatography. J Pharm Biomed Anal. 1992 Oct-Dec;10(10-12):705-15.
[3] Hayashi K, Michiue H, Yamada H, Takata K, Nakayama H, Wei FY, Fujimura A, Tazawa H, Asai A, Ogo N, Miyachi H, Nishiki T, Tomizawa K, Takei K, Matsui H. Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization. Sci Rep. 2016 Mar 18;6:23372. doi: 10.1038/srep23372. PMID: 26988603; PMCID: PMC4796892.
[4] Pasek RC, Dunn JC, Elsakr JM, Aramandla M, Matta AR, Gannon M. Retraction. Am J Physiol Endocrinol Metab. 2017 Jul 1;313(1):E105. doi: 10.1152/ajpendo.zh1-7764-retr.2017. PMID: 28687703; PMCID: PMC6109701.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.8424 mL
- 19.2121 mL
- 38.4243 mL
- 5 mM
- 0.7685 mL
- 3.8424 mL
- 7.6849 mL
- 10 mM
- 0.3842 mL
- 1.9212 mL
- 3.8424 mL

技术信息

CAS号	61718-80-7		储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C13H15F3O2		运输	蓝冰
分子量	260.25		别名	Fluvoxketone

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总药量计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 动物数量只每天给药次给药天

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工作液计算器 ✕

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