|(2S,3S,4R,5R,6R)-5-氨基-2-(氨基甲基)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-二氨基-2-(((2S,3R,4R,5S,6R)-3-氨基-4,5-二羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-6-羟基环己基)氧基)-4-羟基-2-(羟甲基)四氢呋喃-3-基)氧基)四氢-2H-吡喃-3,4-二醇硫酸盐|CsnPharm

CAS No.: 7205-49-4

Synonyms: Paromomycin sulfate salt

Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.

规格	价格	促销价格	库存	数量

400-920-2911

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生物活性

描述Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL^[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects^[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10(-3) M paromomycin sulfate while those of hexokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase were not inhibited^[5]. In addition, with regard to correlation of endotoxemia with renal impairment, endogenous creatinine clearance and p-aminohippurate clearance were significantly improved (P less than 0.02) in those patients whose endotoxemia disappeared on paromomycin sulfate administration. Paromomycin sulfate seems to be effective in the prevention of endotoxemia and the associated renal impairment in cirrhosis in man^[6]. Significantly higher frequencies of resistance to paromomycin, kanamycin, neomycin and tobramycin were observed in S. aureus isolates from PS (paromomycin supplemented) birds. Paromomycin supplementation resulted in resistance to aminoglycosides in bacteria of PS turkeys. Co-selection for resistance to other antimicrobial agents was observed in E. coli isolates^[7].
参考文献

实验方案

技术信息

CAS号

7205-49-4

储存条件

分子式

C23H47N5O18S

运输

蓝冰

分子量

713.71

别名

Paromomycin sulfate salt

溶解度

DMSO	insoluble
Water	430.0 mg/mL (602.5 mM)

动物实验配方

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