生物活性

• 描述Ceftriaxone sodium is a third-generation semi-synthetic antibiotic belonging to the class of cephalosporins. It is administered only by parenteral route and has the ability to cross the blood-brain barrier. It has bactericidal action; its main activity is related to the Gram-negative bacteria, being also able to act against Gram-negative bacilli resistant to the first- and second-generation cephalosporins^[3]. Moreover, Ceftriaxone, one of the beta-lactam antibiotics, is a stimulator of EAAT2 (Excitatory amino acid transporter) expression with neuroprotective effects in both in vitro and in vivo models based in part on its ability to inhibit neuronal cell death by glutamate excitotoxicity^[4]. Ceftriaxone sodium could be successfully delivered rectally when embedded in microspheres formulated with either type A gelatin alone or its admixtures with porcine mucin^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03174236	Malnutrition Severe ... more >> Antibiotic Resistance Antibiotic Toxicity Collapse <<	Phase 3	Not yet recruiting	December 31, 2021	Kenya ... more >> Kilifi County Hospital Not yet recruiting Kilifi, Coast, Kenya, 80108 Contact: Shalton M Mwaringa, RCO    +254 041 75222063    SMwaringa@kemri-wellcome.org    Contact: Caroline A Ogwang, MBChB MSc    +254 041 75222063    COgwang@kemri-wellcome.org    Principal Investigator: James A Berkley, FRCPCH          Coast General Hospital - Study site Not yet recruiting Mombasa, Kenya Contact: Laura M Mwalekwa, RCO    +254709983412    LMwalekwa@kemri-wellcome.org    Contact: Caroline A Ogwang, MBChB MSc    +254 041 75222063    COgwang@kemri-wellcome.org    Mbagathi Hospital Not yet recruiting Nairobi, Kenya Contact: Molly Timbwa, RCO    +254709983476    MTimbwa@kemri-wellcome.org    Contact: Priya Sukhtankar, MRCPCH    +254 730 162000    PSukhtankar@kemri-wellcome.org    Uganda Mbale Regional Referral Hospital Not yet recruiting Mbale, Uganda Contact: Peter Olupot-Olupot, MBChB MPH PhD    +256 772 457217    polupotolupot@yahoo.com Collapse <<
  NCT01723150	Liver Abscess, Pyogenic	Phase 4	Completed	-	Singapore ... more >> Singapore General Hospital Singapore, Singapore, 169856 National University Hospital Singapore, Singapore Tan Tock Seng Hospital Singapore, Singapore Collapse <<
  NCT01207739	Lyme Disease ... more >>Borrelia Infection Collapse <<	Phase 4	Completed	-	Netherlands ... more >> Radboud University Nijmegen Medical Centre Nijmegen, Netherlands, 6500 HB Sint Maartenskliniek Nijmegen, Netherlands, 6522 JV Collapse <<

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• 参考文献

• [1] Guo Y, Yang X, et al. Long-term use of ceftriaxone sodium induced changes in gut microbiota and immune system. Sci Rep. 2017 Feb 21;7:43035.

  [2] Lee SG, Su ZZ, et al. Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. J Biol Chem. 2008 May 9;283(19):13116-23.

  [3] da Trindade MT, Salgado HRN. A Critical Review of Analytical Methods for Determination of Ceftriaxone Sodium. Crit Rev Anal Chem. 2018;48(2):95–101

  [4] Lee SG, Su ZZ, Emdad L, et al. Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. J Biol Chem. 2008;283(19):13116–13123

  [5] Ofokansi KC, Adikwu MU, Okore VC. Preparation and evaluation of mucin-gelatin mucoadhesive microspheres for rectal delivery of ceftriaxone sodium. Drug Dev Ind Pharm. 2007;33(6):691–700

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