|(2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3S,4S,5R,6R)-4-羟基-2-(羟甲基)-6-(((2'R,4S,5'R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5',6a,8a,9-四甲基- 1,3,4,5,6,6a,6b,7,8,8a,8b,9,11a,12,12a,12b-十六氢螺并[萘并[2 '1':4,5]茚并 [2, 1-b]呋喃-10,2'-哌啶]-4-基)氧基)四氢-2H-吡喃-3,5-二基)双(氧基)|CsnPharm

CAS No.: 20311-51-7

澳洲茄边碱 Catalog No. CSN18090

Synonyms: Solamargin;δ-Solanigrine;澳洲茄边碱

Solamargine is a naturally-occuring glycoalkaloid isolated from plants of the Solanaceae family which has been used in trials studying the treatment of Actinic Keratosis.

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生物活性

描述Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer^[3]. Solamargine inhibited the progression of GC (gastric cancer) by regulating lncNeat1_2 via the MAPK (mitogen-activated protein kinase) pathway^[4]. Solamargine reduced HepG2 cell viability in a concentration-dependent manner. At 7.5μM solamargine decreased cell viability by less than 20% in HepG2 cells. A wound healing migration assay and Boyden chamber invasion assay showed that solamargine significantly inhibited in vitro migration and invasion of HepG2 cells. At the highest dose, solamargine decreased cell migration and invasion by more than 70% and 72% in HepG2 cells, respectively. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity^[5]. Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis. Solamargine (72 hours) dramatically inhibits the proliferation of SMMC-7721 and HepG2 cells in a dose- and time-dependent manner. The IC50s are 9.21 and 19.88 μg/ml, respectively^[6]. Solamargine activates the mitochondria-mediated apoptotic pathway in U2OS cells via both p53 transcription-dependent and -independent mechanisms^[7]. Solamargine inhibited the viability of QBC939 cells in a dose-dependent manner. Furthermore, solamargine significantly induced the apoptosis of QBC939 cells and altered the mitochondrial membrane potential of cells^[8].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02085395	Actinic Keratosis ... more >> Bowen's Disease Collapse <<	Phase 2	Completed	-	Taiwan ... more >> National Cheng Kung University Hospital Tainan, Taiwan Collapse <<
NCT02029066	Actinic Keratosis	Phase 1	Completed	-	Taiwan ... more >> National Cheng Kung University Hospital Tainan, Taiwan, 70403 Collapse <<
NCT02559934	Actinic Keratosis	Phase 1	Active, not recruiting	December 2018	Taiwan ... more >> National Cheng Kung University Hospital Tainan, Taiwan, 701 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.1520 mL
- 5.7600 mL
- 11.5200 mL
- 5 mM
- 0.2304 mL
- 1.1520 mL
- 2.3040 mL
- 10 mM
- 0.1152 mL
- 0.5760 mL
- 1.1520 mL

技术信息

CAS号

20311-51-7

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C45H73NO15

运输

蓝冰

分子量

868.06

别名

Solamargin;δ-Solanigrine;澳洲茄边碱

溶解度

DMSO	100.0 mg/mL (115.2 mM)

动物实验配方

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