|(1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)- 3-(1,1-二甲基乙基)六氢-2,4,7b,11-四氢-8-甲基-9H-1,7a-(环氧甲烷)-1H,6aH-环戊[c]呋喃[2,3-b]呋喃[3′,2′:3,4]环戊[1,2-d]呋喃-5,9,12(4H)-三酮|CsnPharm

CAS No.: 15291-76-6

银杏内酯C Catalog No. CSN19411

Synonyms: BN-52022;1,7-dihydroxy Ginkgolide A;银杏内酯C

Ginkgolide C can enhance the cardiac function of rats in the body, is a flavone isolated from Ginkgo biloba leaves.

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400-920-2911

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技术信息

生物活性

描述Ginkgolide C, isolated from Ginkgo biloba, is a diterpene lactone that has multiple biological functions and can improve Alzheimer disease and platelet aggregation. Ginkgolide C also inhibits adipogenesis in 3T3-L1 adipocytes. Ginkgolide C reduced lipid accumulation and increased lipolysis through the sirt1/AMPK pathway in oleic acid-induced fatty liver cells^[3]. GGC (Ginkgolide C) exerts its anti-neoplastic activity through modulating c-Met phosphorylation and may be used as an effective therapy against HCC (hepatocellular carcinoma)^[4]. Ginkgolide C (1, 10, 50, 100, 500 mM) significantly reduces the collagen (10 mg/mL)-stimulated rat platelet aggregation in a dose-dependent manner. Ginkgolide C (50, 100 mM) causes pro-MMP-9 (92-kDa) to form an activated MMP-9 (86-kDa) in collagen-stimulated platelets^[5]. GC (Ginkgolide C) possesses a beneficial effect against MI/R (myocardial ischemia/reperfusion) injury via inflammation inhibition that may involve suppression of CD40-NF-κB signal pathway and downstream inflammatory cytokines expression^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02425436	Intrauterine Growth Restrictio... more >>n (IUGR) Collapse <<	Phase 2	Completed	-	-
NCT03772847	Intravenous Alteplase Thrombol... more >>ysis Neurological Improving Collapse <<	Phase 4	Recruiting	December 1, 2019	China, Zhejiang ... more >> Min Lou Recruiting Hangzhou, Zhejiang, China, 310000 Contact: Zexin Chen 13757118366 HREC2013@126.com Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2707 mL
- 11.3534 mL
- 22.7067 mL
- 5 mM
- 0.4541 mL
- 2.2707 mL
- 4.5413 mL
- 10 mM
- 0.2271 mL
- 1.1353 mL
- 2.2707 mL

技术信息

CAS号

15291-76-6

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H24O11

运输

蓝冰

分子量

440.40

别名

BN-52022;1,7-dihydroxy Ginkgolide A;银杏内酯C

溶解度

DMSO	350.0 mg/mL (794.7 mM)
Water	insoluble

动物实验配方

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