CAS No.: 173334-57-1
Aliskiren/阿利克仑 Catalog No. CSN10240
Synonyms: CGP 60536;CGP60536B;SPP 100
Aliskiren is a renin inhibitor with IC50 of 1.5 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 Renin
IC50:1.5nM- 描述
- 作用机制
动物研究 剂量 Rat: 3 mg/kg - 30 mg/kg[4] (s.c.); 10 mg/kg[4] (i.v.); 1 mg/kg - 30 mg/kg[5] (p.o.), 200 mg/kg[6] (p.o.) Mice: 25 mg/kg[7] (osmotic minipump) Mice: 3 mg/kg - 25 mg/kg[8] (s.c.)
给药途径 s.c., i.v.
动物药代数据 Animal Rats[9] Dose 100 mg/kg (p.o.)
10 mg/kg (i.v.)Administration p.o.
i.v.F 2.4% (p.o.) T1/2 23.1 h (i.v.) Tmax 0.25 h (p.o.)
0.083 h (i.v.)CL 1.2 L/h/kg (i.v.) Cmax 0.27 μmol/L (p.o.)
29.20 μmol/L (i.v.)Vss 7.8 L/kg (i.v.) AUC 3.01 μmol·h/L (p.o.)
12.60 μmol·h/L (i.v.)- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00865020 - - Completed - - NCT00841672 Moderate to Severe Hypertensio... more >>n Collapse << Phase 3 Completed - Germany ... more >> Investigative Site Berlin, Germany Philippines Investigative Site Manilla, Philippines Romania Investigative Site Bucharest, Romania Russian Federation Investigative Site Moscow, Russian Federation Singapore Investigative Site Singapore, Singapore Spain Investigative Site Madrid, Spain Collapse << NCT00841672 - - Completed - - - 更多
- 参考文献
- [1] Wal P, Wal A, et al. Aliskiren: An orally active renin inhibitor. J Pharm Bioallied Sci. 2011 Apr;3(2):189-93.
- [2] Jensen C, Herold P, et al. Aliskiren: the first renin inhibitor for clinical treatment. Nat Rev Drug Discov. 2008 May;7(5):399-410.
- [3] O'Brien E, Barton J, et al. Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker. Hypertension. 2007 Feb;49(2):276-84. Epub 2006 Dec 11.
- [4] Feldman DL, Jin L, et al. Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats. Hypertension. 2008 Jul;52(1):130-6.
- [5] Wood JM, Schnell CR, et al. Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats. J Hypertens. 2005 Feb;23(2):417-26.
- [6] Un H, Bayir Y, et al. The Effects of RAAS Inhibition in Rate Limiting Step by Aliskiren on Testicular Torsion Injury in Rats. J Urol. 2015 Sep;194(3):828-33.
- [7] Higashikuni Y, Takaoka M, et al. Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice. Hypertens Res. 2012 Jan;35(1):62-9.
- [8] Dong YF, Liu L, et al. Aliskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetes. Diabetologia. 2010 Jan;53(1):180-91.
- [9] Aliskiren
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 173334-57-1 | 储存条件 |
|
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| 分子式 | C30H53N3O6 | 运输 | 蓝冰 | |||||
| 分子量 | 551.76 | 别名 | CGP 60536;CGP60536B;SPP 100;Enviage;Rasilez;Riprazo;Sprimeo;阿利克仑 | |||||
| 溶解度 |
|
动物实验配方 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT00865020 | - | - | Completed | - | - |
| NCT00841672 | Moderate to Severe Hypertensio... more >>n Collapse << | Phase 3 | Completed | - | Germany ... more >> Investigative Site Berlin, Germany Philippines Investigative Site Manilla, Philippines Romania Investigative Site Bucharest, Romania Russian Federation Investigative Site Moscow, Russian Federation Singapore Investigative Site Singapore, Singapore Spain Investigative Site Madrid, Spain Collapse << |
| NCT00841672 | - | - | Completed | - | - |
| NCT00219180 | Hypertension | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Germany Investigative Centers, Germany Collapse << |
| NCT00219011 | Heart Failure | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States Germany Investigative Centers, Germany Collapse << |
| NCT01129557 | Proteinuric Kidney Disease ... more >> Diabetic Nephropathy Hypertensive Nephrosclerosis IgA Nephropathy Focal Segmental Glomerulosclerosis Glomerulopathy (Obesity-associated) Glomerulonephritis, Membranous Collapse << | Phase 4 | Terminated | - | United States, New York ... more >> Columbia University Medical Center New York, New York, United States, 10032 Collapse << |
| NCT00417170 | High Blood Pressure ... more >> Metabolic Syndrome Insulin Resistance Endothelial Dysfunction Collapse << | Phase 2 | Completed | - | United States, California ... more >> Novartis Investigative Site Santa Monica, California, United States, 90404 Collapse << |
| NCT00299832 | Hypertension | Phase 3 | Completed | - | Japan ... more >> Novartis Pharmaceuticals Japan, Japan Collapse << |
| NCT00299806 | Hypertension | Phase 3 | Completed | - | Japan ... more >> Novartis Pharmaceuticals Japan, Japan Collapse << |
| NCT01129557 | - | - | Terminated | - | - |
| NCT01048047 | Hypertension | Phase 4 | Unknown | March 2010 | Italy ... more >> University of Pavia Pavia, Italy, 27100 University of Pavia Pavia, Italy Collapse << |
| NCT00760266 | Hypertension | Phase 4 | Completed | - | United States, New Jersey ... more >> Sites in USA East Hanover, New Jersey, United States, 07936 Collapse << |
| NCT00865020 | Hypertension | Phase 4 | Completed | - | Brazil ... more >> Investigative Site Sorocaba, Brazil Canada Investigative Site Gatineau, Canada Ecuador Investigative Site Guayaquil, Ecuador Germany Investigative Site Erfurt, Germany Hungary Invesitagtive Site Budapest, Hungary Korea, Republic of Investigative Site Cheongju, Korea, Republic of Malaysia Investigative Site Kuala Lumpur, Malaysia Mexico Investigative Site Mexico City, Mexico Panama Investigative Site Panama City, Panama Philippines Investigative Site Manila, Philippines Singapore Investigative Site Singapore, Singapore Slovakia Investigative Site Bratislava, Slovakia Spain Investigative Site Sevilla, Spain Turkey Investigative Site Istanbul, Turkey United Kingdom Investigative Site Westbury, United Kingdom Venezuela Investigative Site Caracas, Venezuela Collapse << |
| NCT00870493 | IgA Nephropathy | Phase 3 | Completed | - | Hong Kong ... more >> Prince of Wales Hospital Shatin, Hong Kong Collapse << |
| NCT01125514 | Heart Failure | Phase 2 | Completed | - | Germany ... more >> Novartis Investigative Site Berlin, Germany Lithuania Novartis Investigative Site Vilnius, Lithuania Collapse << |
| NCT00386607 | - | - | Completed | - | - |
| NCT00461136 | Diabetes Type 2 | Phase 1 Phase 2 | Completed | - | Denmark ... more >> Novartis Gentofte, Denmark, 2820 Collapse << |
| NCT00417170 | - | - | Completed | - | - |
| NCT01125514 | - | - | Completed | - | - |
| NCT00819767 | - | - | Completed | - | - |
| NCT00386607 | Hypertension | Phase 3 | Completed | - | United States, California ... more >> Investigative Centers San Diego, California, United States Canada Investigative Centers Canada, Canada Germany Investigative Centers Germany, Germany Netherlands Investigative Centers Netherlands, Netherlands Collapse << |
| NCT00424541 | Hypertension | Phase 1 | Completed | - | Japan ... more >> Novartis Investigative Site Tokyo, Japan, 160-8618 Collapse << |
| NCT00819767 | Hypertension | Phase 2 | Completed | - | Czech Republic ... more >> Investigative Site Pardubice, Czech Republic Investigative Site Prague, Czech Republic Hungary Investigative Site Budapest, Hungary Investigative Site Nyiregyhaza, Hungary Investigative Site Pilisvörösvár, Hungary Investigative Site Szentendre, Hungary Singapore Investigative Site Singapore, Singapore United Kingdom Investigative Site Leicester, United Kingdom Collapse << |
| NCT00760266 | - | - | Completed | - | - |
| NCT00705575 | Hypertension | Phase 3 | Completed | - | United States, New Jersey ... more >> Investigative Site East Hanover, New Jersey, United States, 07936 Argentina Investigative Site Buenos Aires, Argentina Ecuador Investigative Site Quito, Ecuador Germany Investigative Site Berlin, Germany Guatemala Investigative Site Guatemala City, Guatemala Italy Investigative Site Rome, Italy Switzerland Investigative Site Basel, Switzerland Turkey Investigative Site Ankara, Turkey Collapse << |
| NCT00797862 | Hypertension | Phase 3 | Completed | - | Canada ... more >> Investigative Site Toronto, Canada Costa Rica Investigative Site San Jose, Costa Rica France Investigative Site Paris, France Germany Investigative Site Bonn, Germany Greece Investigative Site Athens, Greece Guatemala Investigative Site Guatemala city, Guatemala South Africa Investigative Site Cape Town, South Africa Switzerland Investigative Site Basel, Switzerland United Kingdom Investigative Site London, United Kingdom Venezuela Investigative Site Caracas, Venezuela Collapse << |
| NCT00705575 | - | - | Completed | - | - |
| NCT00923156 | Heart Failure | Phase 2 | Completed | - | Germany ... more >> Novartis Investigator Site Bad Krozingen, Germany, 79189 Novartis Investigator Site Berlin, Germany, 12207 Novartis Investigator Site Berlin, Germany, 13353 Novartis Investigator Site Göttingen, Germany, 37057 Novartis Investigator Site Jena, Germany, 07747 Novartis Investigator Site München, Germany, 80336 Poland Novartis Investigator Site Krakow, Poland, 31-501 Novartis Investigator Site Lublin, Poland, 20-090 Novartis Investigator Site Poznan, Poland, 61-848 Novartis Investigator Site Warszawa, Poland, 02-507 Novartis Investigator Site Wroclaw, Poland, 50-981 Russian Federation Novartis Investigator Site Moscow, Russian Federation, 117292 Novartis Investigator Site Moscow, Russian Federation, 119620 Novartis Investigator Site Moscow, Russian Federation, 121309 Novartis Investigator Site Moscow, Russian Federation, 121552 Novartis Investigative Site Moscow, Russian Federation Collapse << |
| NCT00402103 | Hypertension | Phase 3 | Completed | - | United States, New Mexico ... more >> Investigative Site Santa Fe, New Mexico, United States Belgium Investigator Site Investigative Site, Belgium Denmark Investigative Center Investigative Center, Denmark Finland Investigative Site Investigative Site, Finland Germany Investigative Center Investigative Center, Germany Iceland Investigative Site Investigative Site, Iceland India Investigative Site Investigative Site, India Switzerland Investigative Site Investigative Site, Switzerland Collapse << |
| NCT00797862 | - | - | Completed | - | - |
| NCT00343551 | Essential Hypertension | Phase 3 | Completed | - | Germany ... more >> Investigative Centers, Germany Switzerland Novartis Pharmaceuticals Basel, Switzerland Collapse << |
| NCT00867490 | Hypertension | Phase 3 | Completed | - | Germany ... more >> Investigative Site Chemnitz, Germany Collapse << |
| NCT00923156 | - | - | Completed | - | - |
| NCT00732407 | Diabetes Mellitus ... more >> Atherosclerosis Collapse << | Not Applicable | Unknown | - | - |
| NCT01150357 | - | - | Completed | - | - |
| NCT00402103 | - | - | Completed | - | - |
| NCT00778921 | - | - | Completed | - | - |
| NCT00778921 | Hypertension | Phase 3 | Completed | - | Argentina ... more >> Investigative Site Buenos Aires, Argentina Germany Investigative Site Berlin, Germany Norway Investigative Site Oslo, Norway Poland Investigative Site Warsaw, Poland Slovakia Investigative Site Bratislava, Slovakia Sweden Investigative Site Stockholm, Sweden Turkey Investigative Site Ankara, Turkey Collapse << |
| NCT00777946 | - | - | Completed | - | - |
| NCT01150357 | Hypertension | Phase 3 | Completed | - | - |
| NCT00927394 | Hypertension | Phase 4 | Completed | - | United States, Delaware ... more >> Investigative Site Newark, Delaware, United States, USA United States, Missouri Investigative Site Kansas, Missouri, United States United States, New Jersey Investigative Site Camden, New Jersey, United States United States, Pennsylvania Investigative Site Philadelphia, Pennsylvania, United States Collapse << |
| NCT00867490 | - | - | Completed | - | - |
| NCT00549757 | Type 2 Diabetes Mellitus ... more >> Cardiovascular Disease Collapse << | Phase 3 | Terminated(Lack of benefit and... more >> safety concern) Collapse << | - | - |
| NCT00777946 | Hypertension | Phase 3 | Completed | - | Estonia ... more >> Investigative site Estonia, Estonia France Investigative site France, France Iceland Investigative Site Iceland, Iceland India Investigative Site India, India Italy Investigative site Italy, Italy Korea, Republic of Investigative Site Republic of Korea, Korea, Republic of Lithuania Investigative Site Lithuania, Lithuania Spain Investigative Site Spain, Spain Venezuela Investigative Site Venezuela, Venezuela Collapse << |
| NCT01080768 | - | - | Terminated(Publication of data... more >> from a similar study made the current study redundant.) Collapse << | - | - |
| NCT01893788 | Hypertensive Left Ventricular ... more >>Hypertrophy Collapse << | Phase 4 | Unknown | - | Japan ... more >> Department of Cardiology, Nagoya University Graduate School of Medicine Recruiting Nagoya, Aichi, Japan, 466-8550 Contact: Takanori Nagahiro, MD 81-52-744-2149 t-nagahiro@med.nagoya-u.ac.jp Contact: Toyoaki Murohara, MD, PhD 81-52-744-2149 murohara@med.nagoya-u.ac.jp Collapse << |
| NCT00739596 | Hypertension | Phase 4 | Completed | - | United States, New Jersey ... more >> Sites in USA East Hanover, New Jersey, United States Collapse << |
| NCT01259297 | - | - | Terminated(Terminated early in... more >> agreement with Health Authorities for feasibility reasons) Collapse << | - | - |
| NCT00927394 | - | - | Completed | - | - |
| NCT01305850 | Peritoneal Membrane Failure | Phase 4 | Unknown | October 2011 | Thailand ... more >> Chulalongkorn University Recruiting Bangkok, Thailand, 10330 Contact: Talerngsak Kanjanabuch, Assist. Prf. 662-2564321 ext 211 golfnephro@hotmail.com Principal Investigator: Talerngsak Kanjanabuch, Assist. Prf. Sub-Investigator: Pichaya Tantiyavarong, MD Collapse << |
| NCT01070030 | Stage II Hypertension | Phase 4 | Completed | - | Thailand ... more >> Investigative Site Bangkok, Thailand Investigative Site Chiang Mai, Thailand Investigative Site Nakhon Ratchasima, Thailand Collapse << |
| NCT00881439 | Heart Failure ... more >> Kidney Failure Collapse << | Phase 2 | Terminated(Futility) | - | Netherlands ... more >> University Medical Center Groningen Groningen, Netherlands Collapse << |
| NCT01080768 | Hypertension ... more >>Ankle Edema Collapse << | Phase 2 | Terminated(Publication of data... more >> from a similar study made the current study redundant.) Collapse << | - | Netherlands ... more >> Novartis Investigative Site Beek en Donk, Netherlands Novartis Investigative Site Bosch, Netherlands Novartis Investigative Site Den Haag, Netherlands Novartis Investigative Site Hoogwoud, Netherlands Novartis Investigative Site Lichtenvoorde, Netherlands Novartis Investigative Site Lieshout, Netherlands Novartis Investigative Site Poortvliet, Netherlands Novartis Investigative Site Utrecht, Netherlands Novartis Investigative Site Wildervank, Netherlands Collapse << |
| NCT01259297 | Cardiovascular Events | Phase 3 | Terminated(Terminated early in... more >> agreement with Health Authorities for feasibility reasons) Collapse << | - | - |
| NCT00549757 | - | - | Terminated(Lack of benefit and... more >> safety concern) Collapse << | - | - |
| NCT00739596 | - | - | Completed | - | - |
| NCT01165983 | Diabetes Type 2 | Not Applicable | Completed | - | United States, Massachusetts ... more >> Beth Israel Deaconess Medical Center, Joslin Foot Center & Microcirculation Laboratory Boston, Massachusetts, United States, 02215 Collapse << |
| NCT00773084 | Diastolic Heart Failure | Not Applicable | Withdrawn(Difficulty in recrui... more >>ting patients and then the PI left the institution) Collapse << | August 2009 | United States, Texas ... more >> Texas Tech University Health Sciences Center Lubbock, Texas, United States, 79430 Collapse << |
| NCT00464776 | Diabetes Mellitus, Type 2 | Phase 1 Phase 2 | Completed | - | Denmark ... more >> Novartis Gentofte, Denmark, 2820 Collapse << |
| NCT01042392 | - | - | Completed | - | - |
| NCT00416728 | Healthy | Phase 1 | Completed | - | United States, New Jersey ... more >> Novartis Investigative Site East Hanover, New Jersey, United States, 07936-1080 Collapse << |
| NCT01042392 | Essential Hypertension | Phase 4 | Completed | - | - |
| NCT00787605 | Hypertension ... more >>Diabetes Mellitus Collapse << | Phase 4 | Completed | - | United States, New Jersey ... more >> Sites in USA East Hanover, New Jersey, United States, 07936 Collapse << |
| NCT01165983 | - | - | Completed | - | - |
| NCT00416468 | Healthy | Phase 1 | Completed | - | United States, New Jersey ... more >> Novartis Investigative Site East Hanover, New Jersey, United States, 07936-1080 Collapse << |
| NCT00787605 | - | - | Completed | - | - |
| NCT00542269 | - | - | Terminated(Early termination o... more >>f the study due to slow recruitment.) Collapse << | - | - |
| NCT00542269 | Hypertension With Metabolic Sy... more >>ndrome Collapse << | Phase 4 | Terminated(Early termination o... more >>f the study due to slow recruitment.) Collapse << | - | United Kingdom ... more >> Addenbrookes Hospital Cambridge, United Kingdom Collapse << |
| NCT00464880 | Diabetes Type 2 | Phase 1 Phase 2 | Completed | - | Denmark ... more >> Novartis Gentofte, Denmark, 2820 Collapse << |
| NCT01067326 | - | - | Terminated(Novartis ended all ... more >>studies regarding Aliskiren.) Collapse << | - | - |
| NCT00933920 | Hypertension | Phase 1 | Completed | - | India ... more >> Novartis Investigator Site Coimbatore, India Novartis Investigative Site Hyderabaad, India Novartis Investigator Site Hyderabaad, India Novartis Investigator Site Mangalore, India Novartis Investigative Site New Delhi, India Collapse << |
| NCT01067326 | Endothelial Dysfunction | Phase 3 | Terminated(Novartis ended all ... more >>studies regarding Aliskiren.) Collapse << | - | United States, Minnesota ... more >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 Collapse << |
| NCT01302899 | Non-diabetic Nephropathy | Phase 2 | Terminated(In consequence of t... more >>ermination of ALTITUDE. A number of studies were continued in consultation with the Altitude Data Monitoring Committee.) Collapse << | - | Netherlands ... more >> Novartis Investigative Site Groningen, Netherlands Novartis Investigative Site Leeuwarden, Netherlands Collapse << |
| NCT00797316 | Hypertension | Phase 4 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
| NCT01302899 | - | - | Terminated(In consequence of t... more >>ermination of ALTITUDE. A number of studies were continued in consultation with the Altitude Data Monitoring Committee.) Collapse << | - | - |
| NCT01284114 | Hypertension ... more >>Chronic Kidney Disease Collapse << | Phase 4 | Completed | - | Japan ... more >> Niimi city Yukawa National health insurance clinic Niimi, Okayama, Japan, 719-2643 Konan Hospital Oyama, Tochigi, Japan, 329-0214 Kurosu Hospital Sakura, Tochigi, Japan, 329-1395 Jichi Medical University Shimotsuke, Tochigi, Japan, 3290498 Collapse << |
| NCT01284114 | - | - | Completed | - | - |
| NCT00797316 | - | - | Completed | - | - |
| NCT01150201 | Kidney Disease | Phase 4 | Completed | - | China ... more >> Queen Mary Hospital Hong Kong, China Collapse << |
| NCT01237873 | Essential Hypertension | Phase 3 | Completed | - | Japan ... more >> Novartis Investigative Site Yokohama, Kanagawa, Japan, 231-0023 Novartis Investigative Site Koshigaya city, Saitama, Japan, 343-0826 Novartis Investigative Site Edogawa-ku, Tokyo, Japan, 133-0061 Novartis Investigative Site Katsushika-ku, Tokyo, Japan, 124-0024 Novartis Investigative Site Kiyose, Tokyo, Japan, 204-0021 Novartis Investigative Site Kunitachi, Tokyo, Japan, 186-0001 Novartis Investigative Site Minato-ku, Tokyo, Japan, 105-7390 Novartis Investigative Site Minato-ku, Tokyo, Japan, 108-0075 Novartis Investigative Site Ota-ku, Tokyo, Japan, 143-0023 Novartis Investigative Site Shibuya-ku, Tokyo, Japan, 150-0002 Novartis Investigative Site Shinagawa-ku, Tokyo, Japan, 141-0032 Novartis Investigative Site Tachikawa, Tokyo, Japan, 190-0013 Novartis Investigative Site Toshima-ku, Tokyo, Japan, 171-0021 Collapse << |
| NCT00853957 | - | - | Completed | - | - |
| NCT00768040 | Diabetic Macular Edema | Phase 2 | Terminated(Inadequate enrollme... more >>nt) Collapse << | - | United States, Arizona ... more >> Retinal Consultants of Arizona Phoenix, Arizona, United States United States, California Retina-Vitreous Associates Los Angeles, California, United States United States, Florida National Ophthalmic Research Institute Fort Myers, Florida, United States United States, Georgia Georgia Retina Atlanta, Georgia, United States United States, Maryland Elman Retina Group Baltimore, Maryland, United States United States, Massachusetts Joslin Clinic Boston, Massachusetts, United States, MA United States, Michigan Vitreo-Retinal Associates Grand Rapids, Michigan, United States United States, North Carolina Charlotte Eye, Ear, Nose and Throat Associate Charlotte, North Carolina, United States, NC United States, Ohio Retina-Associates of Cleveland, Inc Beachwood, Ohio, United States United States, Texas Retinal Consultants of Houston Houston, Texas, United States, TX Denmark Novartis Investigative Site Arhus, Denmark Novartis Investigative Site Copenhagen, Denmark Collapse << |
| NCT01715207 | - | - | Completed | - | - |
| NCT00853957 | Hypertension | Phase 4 | Completed | - | United States, Illinois ... more >> Investigative Site Chicago, Illinois, United States United States, Maryland Investigative Site Baltimore, Maryland, United States Investigative Site Oxon Hill, Maryland, United States United States, Michigan Investigative Site Detroit, Michigan, United States United States, New Jersey Investigative Site Trenton, New Jersey, United States United States, New York Investigative Site Brooklyn, New York, United States Investigative Site Springfield Gardens, New York, United States United States, Pennsylvania Investigative Site Philadelphia, Pennsylvania, United States United States, Wisconsin Investigative Site Milwaukeee, Wisconsin, United States Collapse << |
| NCT00894387 | Acute Decompensated Heart Fail... more >>ure Congestive Heart Failure Collapse << | Phase 3 | Completed | - | - |
| NCT00768040 | - | - | Terminated(Inadequate enrollme... more >>nt) Collapse << | - | - |
| NCT00631917 | Hypertension | Phase 4 | Completed | - | United States, Missouri ... more >> Investigative Site Kansas City, Missouri, United States Argentina Investigative Site Investigative Site, Argentina Colombia Investigative Site Investigative Site, Colombia France Investigative Site Investigative Site, France Germany Investigative Site Investigative Site, Germany India Investigative Site investigative Site, India Spain Investigative Site Investigative Site, Spain Collapse << |
| NCT00939588 | Hypertension | Phase 2 | Completed | - | Russian Federation ... more >> Novartis Investigative Site Moscow, Russian Federation Collapse << |
| NCT00765947 | Essential Hypertension ( Mild ... more >>to Moderate) Collapse << | Phase 4 | Completed | - | France ... more >> Investigative Site Paris, France Hungary Investigative Site Budapest, Hungary Romania Investigative Site Bucharest, Romania Slovakia Investigative Site Bratislava, Slovakia Collapse << |
| NCT01060865 | Blood Pressure, High | Phase 4 | Terminated(The participants si... more >>gned an old version of the informed consent.) Collapse << | - | Israel ... more >> Clalit health services Hertsliyah, Hasharon Area, Israel Collapse << |
| NCT01827202 | Hypertension ... more >>Chronic Kidney Disease Proteinuria Collapse << | Phase 4 | Completed | - | Austria ... more >> Medical University of Vienna, Department of Internal Medicine III, Division of Nephrology and Dialysis Vienna, Austria, 1090 Collapse << |
| NCT00809926 | Stage 2 Hypertension | Phase 4 | Completed | - | United States, New Jersey ... more >> Sites in USA East Hanover, New Jersey, United States, 07936 Collapse << |
| NCT00894387 | - | - | Completed | - | - |
| NCT01715207 | Marfan Syndrome | Phase 3 | Completed | - | Korea, Republic of ... more >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 Collapse << |
| NCT00765947 | - | - | Completed | - | - |
| NCT00772577 | Hypertension | Phase 4 | Completed | - | United States, California ... more >> Investigative Site Beverly Hills, California, United States Investigative Site Santa Ana, California, United States United States, Georgia Investigative Site Conyers, Georgia, United States United States, Kentucky Investigative Site Lexington, Kentucky, United States United States, South Carolina Investigative Site Columbia, South Carolina, United States United States, Texas Investigative Site Houston, Texas, United States Collapse << |
| NCT00631917 | - | - | Completed | - | - |
| NCT00809926 | - | - | Completed | - | - |
| NCT00719316 | Chronic Kidney Disease ... more >> Hypertension Muscle Sympathetic Nerve Activity Collapse << | Phase 4 | Unknown | January 2010 | Netherlands ... more >> University Medical Center utrecht Recruiting Utrecht, Netherlands, 3584CX Principal Investigator: Laima Siddiqi, MD Collapse << |
| NCT00772577 | - | - | Completed | - | - |
| NCT00922311 | IgA Nephropathy | Phase 4 | Completed | - | China ... more >> Department of Medicine, The University of Hong Kong Hong Kong, China Queen Mary Hospital Hong Kong, China Collapse << |
| NCT00834041 | - | - | Completed | - | - |
| NCT00853658 | Chronic Heart Failure | Phase 3 | Completed | - | - |
| NCT01417104 | Atherosclerosis | Phase 2 Phase 3 | Terminated(Safety concerns wit... more >>h approved medication identified in an unrelated trial) Collapse << | - | United States, Ohio ... more >> Ohio State University Columbus, Ohio, United States, 43210 Collapse << |
| NCT00667719 | Essential Hypertension | Phase 3 | Completed | - | United States, Texas ... more >> Investigative Site Houston, Texas, United States Belgium Investigative Site Belgium, Belgium Egypt Investigative Site Egypt, Egypt Germany Investigative Site Germany, Germany Poland Investigative Site Poland, Poland Slovakia Investigative Site Slovakia, Slovakia Spain Investigative Site Spain, Spain Turkey Investigative Site Turkey, Turkey Collapse << |
| NCT00834041 | Hypertension | Phase 1 Phase 2 | Completed | - | United States, Kentucky ... more >> Investigative Site Louisville, Kentucky, United States Belgium Investigative Site Brussels, Belgium Brazil Investigative Site Brasilia, Brazil Hungary Investigative Site Budapest, Hungary Poland Investigative Site Warsaw, Poland Collapse << |
| NCT01176032 | Hypertension ... more >>Left Ventricle Hypertrophy Collapse << | Phase 4 | Completed | - | Spain ... more >> Novartis Investigative Site Sanlúcar de Barrameda, Andalucia, Spain, 11540 Novartis Investigative Site Sevilla, Andalucia, Spain, 41009 Novartis Investigative Site Sevilla, Andalucia, Spain, 41013 Novartis Investigative Site Utrera, Andalucia, Spain, 41710 Novartis Investigative Site Burgos, Castilla y Leon, Spain, 09005 Novartis Investigative Site Barcelona, Cataluña, Spain, 08036 Novartis Investigative Site Girona, Cataluña, Spain, 17007 Novartis Investigative Site L'Hospitalet de Llobregat, Cataluña, Spain, 08907 Novartis Investigative Site Santa Coloma de Gramanet, Cataluña, Spain Novartis Investigative Site Alicante, Comunidad Valenciana, Spain, 03004 Novartis Investigative Site Torrevieja (Alicante), Comunidad Valenciana, Spain, 03186 Novartis Investigative Site Valencia, Comunidad Valenciana, Spain, 46010 Novartis Investigative Site Valencia, Comunidad Valenciana, Spain, 46014 Novartis Investigative Site Santiago de Compostela, Galicia, Spain, 15706 Novartis Investigative Site Galdakano, Pais Vasco, Spain, 48960 Novartis Investigative Site Bilbao, País Vasco, Spain, 48013 Novartis Investigative Site Vitoria, País Vasco, Spain Novartis Investigative Site Barcelona, Spain, 08006 Novartis Investigative Site Barcelona, Spain, 08025 Novartis Investigative Site Madrid, Spain, 28009 Novartis Investigative Site Madrid, Spain, 28035 Novartis Investigative Site Madrid, Spain, 28040 Novartis Investigative Site Madrid, Spain, 28041 Novartis Investigative Site Madrid, Spain, 28046 Novartis Investigative Site Santander, Spain, 39008 Collapse << |
| NCT01409408 | Hypertension ... more >>Diabetes Mellitus Collapse << | Phase 4 | Withdrawn(Due to preliminary r... more >>esults of Altitude Trial.) Collapse << | December 2013 | Brazil ... more >> Hospital Universitario Pedro Ernesto Rio de Janeiro, Brazil, 20551030 Collapse << |
| NCT01417104 | - | - | Terminated(Safety concerns wit... more >>h approved medication identified in an unrelated trial) Collapse << | - | - |
| NCT00853658 | - | - | Completed | - | - |
| NCT01176032 | - | - | Completed | - | - |
| NCT00654875 | Essential Hypertension | Phase 4 | Completed | - | United States, Ohio ... more >> Investigative Site Zanesville, Ohio, United States Germany Investigative Site Frankfurt, Germany Spain Investigative Site Valencia, Spain Collapse << |
| NCT01113047 | Essential Hypertension | Phase 3 | Completed | - | Germany ... more >> Investigative Site Pirna, Germany Collapse << |
| NCT00654875 | - | - | Completed | - | - |
| NCT01472796 | Hypertension | Phase 4 | Unknown | March 2014 | United States, Michigan ... more >> Wayne State University, 4201 St. Antoine Recruiting Detroit, Michigan, United States, 48201 Contact: Carol A Muzyk, CCRP 313-745-2378 cmuzyk@med.wayne.edu Contact: Donna Ford 888-235-5467 Principal Investigator: John M Flack, M.D., M.P.H. Collapse << |
| NCT00414609 | Myocardial Infarction | Phase 3 | Completed | - | - |
| NCT01056731 | High Blood Pressure | Phase 4 | Completed | - | Venezuela ... more >> Investigative Site Bolíva, Venezuela Investigative Site Carabobo, Venezuela Investigative Site Caracas, Venezuela Investigative Site Edo Zulia, Venezuela Investigative Site Estado Monagas, Venezuela Investigative Site Falcón, Venezuela Investigative Site Maracaibo Estado Zulia, Venezuela Collapse << |
| NCT00414609 | - | - | Completed | - | - |
| NCT01318395 | Arterial Hypertension | Phase 3 | Completed | - | Germany ... more >> Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg Erlangen, Germany, 91054 Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg Nürnberg, Germany, 90471 Collapse << |
| NCT00498433 | Hypertension ... more >>Abdominal Obesity Collapse << | Phase 2 | Terminated(Early termination r... more >>esulted from interim analysis of the ALTITUDE trial) Collapse << | - | Germany ... more >> Novartis Investigative Site Berlin-Buch, Germany, 13125 Novartis Investigative Site Hannover, Germany, 30159 Collapse << |
| NCT00518765 | Hypertension | Phase 3 | Completed | - | United States, Massachusetts ... more >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Collapse << |
| NCT01922141 | Hypertension | Phase 4 | Withdrawn | June 2018 | - |
| NCT00660309 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | United States, Massachusetts ... more >> Novartis Investigator Site Boston, Massachusetts, United States, 02115 Collapse << |
| NCT00498433 | - | - | Terminated(Early termination r... more >>esulted from interim analysis of the ALTITUDE trial) Collapse << | - | - |
| NCT00660309 | - | - | Completed | - | - |
| NCT00994253 | Hypertension ... more >>Diabetes Type 2 Collapse << | Phase 4 | Withdrawn(Due to safety concer... more >>ns re the concomitant use of aliskiren with an ACEi or ARB.) Collapse << | December 2012 | United States, Michigan ... more >> William Beaumont Hospital Royal Oak, Michigan, United States, 48073 Collapse << |
| NCT00942994 | Hypertension | Phase 4 | Completed | - | United States, Arkansas ... more >> K and S Research Services Little Rock, Arkansas, United States, 72201 United States, Florida Well Pharma Medical Research South Miami, Florida, United States, 33143 United States, Massachusetts Hyde Park Health Associates Mattapan, Massachusetts, United States, 02126 United States, Virginia Manassas Clinical Research Center Manassas, Virginia, United States, 20110 United States, Washington Scriber Kidney Center Seattle, Washington, United States, 98133 Collapse << |
| NCT01394770 | Hypertension ... more >>Dialysis Collapse << | Phase 4 | Unknown | September 2012 | Italy ... more >> Second Univesity of Naples Naples, Italy, 80100 Collapse << |
| NCT01040494 | Congestive Heart Failure | Phase 4 | Unknown | January 2011 | Taiwan ... more >> National Taiwan University Hospital Not yet recruiting Taipei, Taiwan, 886 Contact: Lian-Yu Lin, MD, PhD +886-2-23123456 ext 65002 lin7010@ms1.hinet.net Principal Investigator: Lian-Yu Lin, MD, PhD Taipei Veteral General Hospital Not yet recruiting Taipei, Taiwan, 886 Contact: Chen-Huan Chen, MD, PhD +886-2-8712121 ext 2073 chench@vghtpe.gov.tw Principal Investigator: Chen-Huan Chen, MD, PhD Collapse << |
| NCT01219413 | Chronic Kidney Disease ... more >> Proteinuria Blood Pressure Collapse << | Phase 4 | Completed | - | Poland ... more >> Medical University of Gdansk Gdansk, Pomorskie, Poland, 80-211 Collapse << |
| NCT00441064 | Hypertension | Phase 4 | Completed | - | United States, California ... more >> Novartis US Orangevale, California, United States United States, Minnesota Novartis US Brooklyn Center, Minnesota, United States United States, Montana Novartis US Butte, Montana, United States Novartis US Missoula, Montana, United States United States, Nebraska Novartis US Lincoln, Nebraska, United States United States, New York Novartis US Johnson City, New York, United States United States, North Carolina Novartis US Asheboro, North Carolina, United States Novartis US Shelby, North Carolina, United States United States, Ohio Novartis US Cincinnati, Ohio, United States Novartis US Kettering, Ohio, United States United States, Pennsylvania Novartis US Downington, Pennsylvania, United States Novartis US Erie, Pennsylvania, United States Novartis US Pittsburg, Pennsylvania, United States United States, Texas Novartis US Dallas, Texas, United States Novartis US Kingsport, Texas, United States United States, Utah Novartis US Bountiful, Utah, United States Novartis US Salt Lake City, Utah, United States United States, Washington Novartis US Port Orchard, Washington, United States United States, Wisconsin Novartis US Madison, Wisconsin, United States Collapse << |
| NCT01095822 | Diabetes Mellitus | Phase 4 | Unknown | March 2011 | United States, Maryland ... more >> Dr. Pokov's Polyclinic. 6821 Reisterstown Road Suite 206 Baltimore, Maryland, United States, 21215 Collapse << |
| NCT00529451 | - | - | Completed | - | - |
| NCT00529451 | Hypertension | Phase 3 | Completed | - | China ... more >> Novartis Investigative Sites China, China India Novartis Investigative Sites India, India Thailand Novartis Investigative Sites Thailand, Thailand Collapse << |
| NCT00441064 | - | - | Completed | - | - |
| NCT02909166 | Atrial Fibrillation | Phase 3 | Unknown | December 2017 | Finland ... more >> Helsinki University Central Hospital Recruiting Helsinki, Finland, 00029 Contact: Mika Lehto, MD, PhD +358505447487 mika.lehto@hus.fi Contact: Jussi Niiranen, MD jussi.niiranen@hus.fi Collapse << |
| NCT01519635 | Hypertension | Phase 4 | Unknown | October 2012 | Switzerland ... more >> Centre Hospitalier Universitaire Vaudois Recruiting Lausanne, Vaud, Switzerland, 1004 Contact: Michel Burnier, Professor 0041213141129 michel.burnier@huv.ch Sub-Investigator: Valentina Forni, MD Collapse << |
| NCT02446548 | Albuminuria | Not Applicable | Completed | - | Poland ... more >> Medical University of Gdansk Gdansk, Pomorskie, Poland, 80-211 Collapse << |
| NCT01349114 | - | - | Terminated(Sponsor requested t... more >>ermination.) Collapse << | - | - |
| NCT01235910 | - | - | Terminated(Study was stopped e... more >>arly due to difficulty finding patients who met I/E criteria.) Collapse << | - | - |
| NCT01349114 | Diabetes Pre-... more >>hypertension Hypertension Collapse << | Phase 4 | Terminated(Sponsor requested t... more >>ermination.) Collapse << | - | United States, Alabama ... more >> UAB Birmingham, Alabama, United States, 35294 Collapse << |
| NCT00949351 | Type 2 Diabetes With Nephropat... more >>hy Collapse << | Phase 4 | Unknown | September 2010 | Thailand ... more >> Lerdsin General Hospital Not yet recruiting Bangkok, Thailand, 10500 Contact: Krissanapong Manotham, Dr 662 3539799 ext 2501 kmanotham@hotmail.com Contact: Tanaporn Ratanasuwan, Dr tratanas@hotmail.com Principal Investigator: Krissanapong Manotham, Dr Collapse << |
| NCT00982033 | - | - | Completed | - | - |
| NCT01437943 | Kidney Disease ... more >> Kidney Failure, Chronic Collapse << | Phase 4 | Terminated(Novartis has have d... more >>ecided to terminate all clinical investigator-initiated research projects involving aliskiren) Collapse << | - | United States, Massachusetts ... more >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Collapse << |
| NCT01437943 | - | - | Terminated(Novartis has have d... more >>ecided to terminate all clinical investigator-initiated research projects involving aliskiren) Collapse << | - | - |
| NCT01093781 | Idiopathic Membranous Nephropa... more >>thy Collapse << | Not Applicable | Withdrawn(Manufacturer asked t... more >>o close study due to AEs experienced by subjects in other studies.) Collapse << | - | United States, Minnesota ... more >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 Collapse << |
| NCT01480791 | Hypertension ... more >>Diabetes Collapse << | Phase 2 | Withdrawn(Because of results o... more >>f Altitude trial, this trial was cancelled.) Collapse << | - | Canada, Quebec ... more >> Cardiovascular Prevention Centre, Jewish General Hospital Montreal, Quebec, Canada, H3T 1E2 Collapse << |
| NCT01570686 | Hypertension | Phase 4 | Completed | - | - |
| NCT01570686 | - | - | Completed | - | - |
| NCT01568775 | End Stage Renal Disease | Phase 1 | Completed | - | Germany ... more >> Charité Universitätsmedizin Berlin, Germany Collapse << |
| NCT00982033 | Heart Failure | Phase 4 | Completed | - | United States, North Carolina ... more >> Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 Collapse << |
| NCT00942994 | - | - | Completed | - | - |
| NCT01235910 | Hypertension ... more >>Cardiac Transplantation Collapse << | Phase 4 | Terminated(Study was stopped e... more >>arly due to difficulty finding patients who met I/E criteria.) Collapse << | - | United States, Colorado ... more >> University of Colorado Denver Aurora, Colorado, United States, 80045 Collapse << |
| 靶点 | Description | IC50 |
|---|---|---|
| Renin | IC50:1.5nM |
