CAS No.: 1002304-34-8
AMG-208 Catalog No. CSN16548
Synonyms: AMG-208
AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00813384 Cancer Oncolo... more >>gy Tumors Advanced Malignancy Advanced Solid Tumors Oncology Patients Collapse << Phase 1 Completed - United States, California ... more >> Research Site Beverly Hills, California, United States, 90211 United States, Missouri Research Site St Louis, Missouri, United States, 63110 United States, Texas Research Site Houston, Texas, United States, 77030 Collapse << NCT02420587 Prostate Cancer Phase 2 Withdrawn - United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << - 参考文献
- [1] Boezio AA, Berry L, et al. Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6307-12.
- [2] Albrecht BK, Harmange JC, et al. Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase. J Med Chem. 2008 May 22;51(10):2879-82.
- [3] Hong DS, Rosen P, Lockhart AC, Fu S, Janku F, Kurzrock R, Khan R, Amore B, Caudillo I, Deng H, Hwang YC, Loberg R, Ngarmchamnanrith G, Beaupre DM, Lee P. A first-in-human study of AMG 208, an oral MET inhibitor, in adult patients with advanced solid tumors. Oncotarget. 2015 Jul 30;6(21):18693-706. doi: 10.18632/oncotarget.4472. PMID: 26155941; PMCID: PMC4621921.
- [4] Boezio AA, Berry L, Albrecht BK, Bauer D, Bellon SF, Bode C, Chen A, Choquette D, Dussault I, Fang M, Hirai S, Kaplan-Lefko P, Larrow JF, Lin MH, Lohman J, Potashman MH, Qu Y, Rex K, Santostefano M, Shah K, Shimanovich R, Springer SK, Teffera Y, Yang Y, Zhang Y, Harmange JC. Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6307-12. doi: 10.1016/j.bmcl.2009.09.096. Epub 2009 Sep 27. Erratum in: Bioorg Med Chem Lett. 2010 Jan 15;20(2):773. Fang, Mei [added]; Qu, Yusheng [added]. PMID: 19819693.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1002304-34-8 | 储存条件 |
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| 分子式 | C22H17N5O2 | 运输 | 蓝冰 | |||||||||
| 分子量 | 383.40 | 别名 | AMG-208 | |||||||||
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动物实验配方 |
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