CAS No.: 14028-44-5
Amoxapine/阿莫沙平 Catalog No. CSN10295
Synonyms: CL-67772;Asendin;Asendis
Amoxapine, a tricyclic dibenzoxazepine antidepressant, inhibits GLYT2a transport activity with IC50 of 92 μM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 作用机制
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00704860 Major Depression Phase 4 Completed - Canada, Ontario ... more >> University of Ottawa Institute of Mental Health Research Ottawa, Ontario, Canada, K1Z 7K4 Collapse << NCT00000317 Cocaine-Related Disorders ... more >> Substance-Related Disorders Collapse << Phase 2 Completed - United States, New York ... more >> NYS Psychiatric Institute New York, New York, United States, 10032 Collapse << - 参考文献
- [1] Obers S, Staudacher I, et al. Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine. Naunyn Schmiedebergs Arch Pharmacol. 2010 May;381(5):385-400.
- [2] Núnez E, Lopez-Corcuera B, et al. Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters. Br J Pharmacol. 2000 Jan;129(1):200-6.
- [3] Tatsumi M, Groshan K, Blakely RD, Richelson E. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997;340(2-3):249-258. doi:10.1016/s0014-2999(97)01393-9
- [4] Núñez E, López-Corcuera B, Vázquez J, Giménez C, Aragón C. Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters. Br J Pharmacol. 2000;129(1):200-206. doi:10.1038/sj.bjp.0703049
- [5] Kong R, Liu T, Zhu X, et al. Old drug new use--amoxapine and its metabolites as potent bacterial β-glucuronidase inhibitors for alleviating cancer drug toxicity. Clin Cancer Res. 2014;20(13):3521-3530. doi:10.1158/1078-0432.CCR-14-0395
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 14028-44-5 | 储存条件 |
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| 分子式 | C17H16ClN3O | 运输 | 蓝冰 | |||||||||||
| 分子量 | 313.78 | 别名 | CL-67772;Asendin;Asendis;Defanyl;Demolox;Oxamine;Amolife;Oxcap;Adisen;Amoxan;阿莫沙平 | |||||||||||
| 溶解度 |
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动物实验配方 |
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