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CAS No.: 916151-99-0
Synonyms: LOR-253;LT-253
APTO-253 is a small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Kruppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death.
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生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT02267863 | Acute Myelogenous Leukemia in ... more >>Relapse Acute Myelogenous Leukemia, Relapsed, Adult Acute Myelogenous Leukemia, Adult Acute Myelogenous Leukemia High Risk Myelodysplasia Collapse << | Phase 1 | Recruiting | June 2020 | United States, Arizona ... more >> University of Arizona Cancer Center Recruiting Tucson, Arizona, United States, 85724 Contact: Crystal Placencia 520-694-1231 CPlacencia@uacc.arizona.edu Contact: Melissa Lim 520-626-9526 mlim@uacc.arizona.edu Principal Investigator: Daruka Mahadevan, M.D Sub-Investigator: Hani Babiker, M.D Sub-Investigator: Sandra Kurtin, ANP-C Sub-Investigator: Lois Lattimore, ANP-C Sub-Investigator: Keri Maher, DO Sub-Investigator: Laura McPheeters, FNP United States, Michigan University of Michigan Not yet recruiting Ann Arbor, Michigan, United States, 48109 Principal Investigator: Patrick Burke, MD United States, Ohio University Hospital Not yet recruiting Cleveland, Ohio, United States, 44106 Contact: Donna Kane, RN 216-844-8123 donna.kane@UHhospitals.org United States, Texas Baylor Research Institute Recruiting Dallas, Texas, United States, 75246 Contact: Erica Goetz, RN, BSN 214-818-8325 erica.goetz@baylorhealth.edu Principal Investigator: Moshe Y. Levy, MD MD Anderson Cancer Center Not yet recruiting Houston, Texas, United States, 77030 Principal Investigator: Maro Ohanian, DO Collapse << |
实验方案
技术信息
CAS号 | 916151-99-0 | 储存条件 |
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分子式 | C22H14FN5 | 运输 | 蓝冰 | |||||||
分子量 | 367.38 | 别名 | LOR-253;LT-253 | |||||||
溶解度 |
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动物实验配方 |