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CAS No.: 649749-10-0

ATN-224 Catalog No. CSN18374

Synonyms: Bis-Choline Tetrathiomolybdate;Bis(choline)tetrathiomolybdate;Decuprate

ATN-224, a copper-chelator agent, can inhibit intracellular SOD1 with IC50 of 17.5 nM.

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实验方案

技术信息

生物活性

描述ATN-224 is a copper-chelator agent which can inhibit intracellular SOD1 activity with IC50 of 17.5 nM.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03403205	Wilson Disease	Phase 3	Recruiting	February 14, 2024	United States, California ... more >> Clinical Trial Site Recruiting Los Angeles, California, United States, 90095 United States, Connecticut Clinical Trial Site Recruiting New Haven, Connecticut, United States, 06510 United States, Illinois Clinical Trial Site Recruiting Chicago, Illinois, United States, 60611 United States, Michigan Clinical Trial Site Recruiting Ann Arbor, Michigan, United States, 48109 United States, Tennessee Clinical Trial Site Recruiting Nashville, Tennessee, United States, 37240-7915 United States, Texas Clinical Trial Site Recruiting Houston, Texas, United States, 77030 United States, Washington Clinical Trial Site Recruiting Seattle, Washington, United States, 98105 Austria Clinical Trial Site Recruiting Graz, Austria, 8036 Clinical Trial Site Recruiting Innsbruck, Austria, 6020 Clinical Trial Site Recruiting Wien, Austria, 1090 Germany Clinical Trial Site Recruiting Dresden, Germany, 01307 Clinical Trial Site Recruiting Hamburg, Germany, 20099 Clinical Trial Site Recruiting Heidelberg, Germany, 69120 Clinical Trial Site Recruiting Leipzig, Germany, 04103 Poland Clinical Trial Site Recruiting Warszawa, Poland, 02-957 Spain Clinical Trial Site Recruiting Majadahonda, Spain, 28222 Clinical Trial Site Recruiting Sabadell, Spain, E-08208 United Kingdom Clinical Trial Site Recruiting Birmingham, United Kingdom, B15 2PR Clinical Trial Site Recruiting Cambridge, United Kingdom, CB2 0OQ Clinical Trial Site Recruiting Guildford, United Kingdom, GU2 7XX Collapse <<
NCT00176774	Colorectal Carcinoma	Phase 2	Completed	-	United States, Michigan ... more >> University of Michigan Cancer Center Ann Arbor, Michigan, United States, 48109 Collapse <<
NCT00004339	Wilson Disease	Phase 3	Completed	-	United States, Michigan ... more >> University of Michigan Ann Arbor, Michigan, United States, 48109 Collapse <<

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参考文献

[1] Juarez JC, Betancourt O Jr, et al. Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82.
[2] Donate F, Juarez JC, et al. Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224). Br J Cancer. 2008 Feb 26;98(4):776-83.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3119 mL
- 11.5596 mL
- 23.1192 mL
- 5 mM
- 0.4624 mL
- 2.3119 mL
- 4.6238 mL
- 10 mM
- 0.2312 mL
- 1.1560 mL
- 2.3119 mL

技术信息

CAS号	649749-10-0	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C10H28MoN2O2S4	运输	蓝冰
分子量	432.54	别名	Bis-Choline Tetrathiomolybdate;Bis(choline)tetrathiomolybdate;Decuprate

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03403205	Wilson Disease	Phase 3	Recruiting	February 14, 2024	United States, California ... more >> Clinical Trial Site Recruiting Los Angeles, California, United States, 90095 United States, Connecticut Clinical Trial Site Recruiting New Haven, Connecticut, United States, 06510 United States, Illinois Clinical Trial Site Recruiting Chicago, Illinois, United States, 60611 United States, Michigan Clinical Trial Site Recruiting Ann Arbor, Michigan, United States, 48109 United States, Tennessee Clinical Trial Site Recruiting Nashville, Tennessee, United States, 37240-7915 United States, Texas Clinical Trial Site Recruiting Houston, Texas, United States, 77030 United States, Washington Clinical Trial Site Recruiting Seattle, Washington, United States, 98105 Austria Clinical Trial Site Recruiting Graz, Austria, 8036 Clinical Trial Site Recruiting Innsbruck, Austria, 6020 Clinical Trial Site Recruiting Wien, Austria, 1090 Germany Clinical Trial Site Recruiting Dresden, Germany, 01307 Clinical Trial Site Recruiting Hamburg, Germany, 20099 Clinical Trial Site Recruiting Heidelberg, Germany, 69120 Clinical Trial Site Recruiting Leipzig, Germany, 04103 Poland Clinical Trial Site Recruiting Warszawa, Poland, 02-957 Spain Clinical Trial Site Recruiting Majadahonda, Spain, 28222 Clinical Trial Site Recruiting Sabadell, Spain, E-08208 United Kingdom Clinical Trial Site Recruiting Birmingham, United Kingdom, B15 2PR Clinical Trial Site Recruiting Cambridge, United Kingdom, CB2 0OQ Clinical Trial Site Recruiting Guildford, United Kingdom, GU2 7XX Collapse <<
NCT00176774	Colorectal Carcinoma	Phase 2	Completed	-	United States, Michigan ... more >> University of Michigan Cancer Center Ann Arbor, Michigan, United States, 48109 Collapse <<
NCT00004339	Wilson Disease	Phase 3	Completed	-	United States, Michigan ... more >> University of Michigan Ann Arbor, Michigan, United States, 48109 Collapse <<
NCT00560495	Lung Cancer	Phase 1	Withdrawn	-	United States, New York ... more >> Roswell Park Cancer Institute Buffalo, New York, United States, 14263-0001 Collapse <<
NCT00006332	Carcinoma, Hepatocellular	Phase 2	Completed	-	United States, Michigan ... more >> 3912 Taubman Center Ann Arbor, Michigan, United States, 48109-0362 Collapse <<
NCT00805805	Primary Biliary Cirrhosis	Phase 3	Completed	-	United States, Michigan ... more >> University of Michigan Ann Arbor, Michigan, United States, 48109 Collapse <<
NCT00189176	Idiopathic Pulmonary Fibrosis	Phase 1 Phase 2	Completed	-	United States, Michigan ... more >> University of Michigan Health System Ann Arbor, Michigan, United States, 48109 Collapse <<
NCT00176800	Esophageal Carcinoma	Phase 2	Completed	-	United States, Michigan ... more >> University of Michigan Cancer Center Ann Arbor, Michigan, United States, 48109 Collapse <<
NCT00195091	Breast Cancer	Phase 2	Active, not recruiting	June 2020	United States, New York ... more >> Weill Medical College of Cornell University New York, New York, United States, 10021 Collapse <<
NCT01837329	Non-Small Cell Lung Cancer	Phase 1	Recruiting	October 2018	United States, New York ... more >> University of Rochester Recruiting Rochester, New York, United States, 14642 Contact: Amy Jasek 585-273-1912 Amy_Jasek@urmc.rochester.edu Principal Investigator: David Dougherty, MD Collapse <<
NCT00383851	Melanoma	Phase 2	Unknown	September 2008	United States, Arizona ... more >> Arizona Cancer Center Tucson, Arizona, United States, 85724 United States, California Pacific Oncology and Hematology Encinitas, California, United States, 92024 Hematology - Oncology Group of Orange, Inc. Orange, California, United States, 92868 UCI Chao Family Comprehensive Cancer Center Orange, California, United States, 92868 The Angeles Clinic Santa Monica, California, United States, 90404 United States, Colorado University of Colorado Health Science Center Denver, Colorado, United States, 80262 United States, Florida Florida Cancer Specialists Fort Myers, Florida, United States, 33901 United States, Louisiana Hematology and Oncology Specialists, LLC Metairie, Louisiana, United States, 70006 United States, Maryland The Harry and Jeanette Weinberg Cancer Institute at Franklin Square Baltimore, Maryland, United States, 21237 Center for Cancer and Blood Disorders Bethesda, Maryland, United States, 20817 United States, Montana Billings Clinic Billings, Montana, United States, 59101 United States, New Jersey Mountainside Hospital Cancer Center - The Melanoma Center Montclair, New Jersey, United States, 07042 United States, Ohio Oncology Hematology Care Cincinati, Ohio, United States, 45242 United States, South Carolina Cancer Center of the Carolinas Greenville, South Carolina, United States, 29605 United States, Tennessee Chattanooga Oncology and Hematology Associates Chattanooga, Tennessee, United States Tennessee Oncology Nashville, Tennessee, United States, 37203 United States, Texas Mary Crowley Medical Research Center Dallas, Texas, United States, 75246 Collapse <<
NCT00113542	Psoriasis	Phase 2	Completed	-	United States, Michigan ... more >> University of Michigan Department of Dermatology Ann Arbor, Michigan, United States, 48109 Collapse <<
NCT00674557	Breast Cancer	Phase 2	Terminated(Withdrawn as the cl... more >>inical development of ATN-224 was terminated by the drug company who was providing ATN-224 for the study) Collapse <<	-	United Kingdom ... more >> Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford Oxford, England, United Kingdom, OX3 7LJ Collapse <<
NCT00176800	-	-	Completed	-	-
NCT00352742	Multiple Myeloma	Phase 1 Phase 2	Terminated	December 2008	United States, California ... more >> Hematolgy-Oncology Medical Group of Fresno, Inc. Fresno, California, United States, 93720 Institute for Myeloma and Bone Cancer Research West Hollywood, California, United States, 90069 United States, Florida Florida Cancer Specialists Fort Myers, Florida, United States, 33901 United States, Maryland Center for Cancer and Blood Disorders Bethesda, Maryland, United States, 20817 United States, Montana Billings Clinic Billings, Montana, United States, 59101 United States, New Jersey The Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, New York SUNY Downstate Brooklyn, New York, United States, 11203 Roswell Park Cancer Institute Buffalo, New York, United States, 14263 United States, Texas Mary Crowley Medical Research Center Dallas, Texas, United States, 75246 Tyler Cancer Center Tyler, Texas, United States, 75702 Collapse <<
NCT00150995	Prostate Cancer	Phase 2	Completed	-	United States, Michigan ... more >> The University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 Collapse <<
NCT00405574	Prostate Cancer	Phase 2	Unknown	September 2008	United States, California ... more >> University of California San Francisco San Francisco, California, United States, 94143 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University Baltimore, Maryland, United States, 21205 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10021 United States, Oregon Oregon Health and Science University Portland, Oregon, United States, 97239 United States, Texas University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 United States, Wisconsin University of Wisconsin Paul P. Carbone Comprehensive Cancer Center Madison, Wisconsin, United States, 53792 Collapse <<

ATN-224 Catalog No. CSN18374

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