CAS No.: 603148-36-3
Azeliragon/阿齐瑞格 Catalog No. CSN17246
Synonyms: TTP488;PF-04494700;阿齐瑞格
Azeliragon is an orally bioavailable inhibitor of the receptor for advanced glycation endproducts (RAGE) with Kd of 12.7 nM for human recombinant sRAGE. While RAGE transports amyloid-β (Aβ) from plasma into the CNS, Azeliragon is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer's disease (AD).
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02916056 Alzheimer's Disease Phase 3 Terminated(Not due to safety b... more >>ut due to a lack of efficacy at the 5 mg azeliragon dose.) Collapse << - - NCT02080364 Alzheimer's Disease Phase 3 Terminated(Not due to safety b... more >>ut due to a lack of efficacy at the 5 mg azeliragon dose.) Collapse << - - - 参考文献
- [1] Saito S, Ihara M. New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy. Front Aging Neurosci. 2014 Oct 20;6:290.
- [2] Burstein AH, Grimes I, Galasko DR, Aisen PS, Sabbagh M, Mjalli AM. Effect of TTP488 in patients with mild to moderate Alzheimer's disease. BMC Neurol. 2014 Jan 15;14:12.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 603148-36-3 | 储存条件 |
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| 分子式 | C32H38ClN3O2 | 运输 | 蓝冰 | |||||
| 分子量 | 532.12 | 别名 | TTP488;PF-04494700;阿齐瑞格 | |||||
| 溶解度 |
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动物实验配方 |
