|N1-(3,4-二氯苯乙基)-N1,N2,N2-三甲基乙-1,2-二胺二溴化氢盐|CsnPharm

CAS No.: 138356-21-5

BD-1047 2HBr/BD 1047二氢溴酸盐 Catalog No. CSN16267

Synonyms: BD-1047 HBr;BD 1047 (hydrobromide);BD-1047

BD-1047 dihydrobromide is a selective functional antagonist of sigma receptors, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.

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生物活性

描述BD-1047 Dihydrobromide is a selective functional antagonist of sigma-1 receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia. BD 1047 did not decrease amphetamine-induced hyperactivity in mice in a statistically significant manner. Likewise, it did not modify the hyperactivity induced by NMDA receptor antagonists, phencyclidine, memantine or dizocilpine. On the other hand, BD 1047 (1-10 mg/kg; i.p.) attenuated apomorphine-induced climbing in mice and phencyclidine-induced head twitches in rats, like rimcazole and panamesine did^[3]. BD-1047 Dihydrobromide prevents that Cutamesine reduces the cell death rate induced by light exposure in murine photoreceptor-derived 661w cells. BD-1047 attenuates that Cutamesine reduces the mitochondrial damage and the elevated level of caspase 3/7 activity^[4]. Intrathecal (i.t.) pretreatment with the selective sigma-1 receptor antagonist, BD-1047 dihydrobromide (10-100 nmol) dose dependently reduced formalin-induced pain behaviors in second phase, but not first phase, of the formalin test. I.t. injection of BD-1047 also reduced formalin-evoked Fos expression and pNR1 at the protein kinase C-dependent site, serine-896 (Ser896) and the protein kinase A-dependent site, serine-897 (Ser897) in spinal dorsal horn.i.t^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2881 mL
- 11.4406 mL
- 22.8811 mL
- 5 mM
- 0.4576 mL
- 2.2881 mL
- 4.5762 mL
- 10 mM
- 0.2288 mL
- 1.1441 mL
- 2.2881 mL

技术信息

CAS号

138356-21-5

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H22Br2Cl2N2

运输

蓝冰

分子量

437.04

别名

BD-1047 HBr;BD 1047 (hydrobromide);BD-1047

溶解度

DMSO	48.0 mg/mL (109.8 mM)
Water	85.0 mg/mL (194.5 mM)
Ethanol	Insoluble

动物实验配方

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BD-1047 2HBr/BD 1047二氢溴酸盐 Catalog No. CSN16267

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