|[(1-苄基-1H-吲唑-3-基)氧]乙酸|CsnPharm

CAS No.: 20187-55-7

Bendazac/苄达酸 Catalog No. CSN23633

Synonyms: bendazolic acid;AF-983;2-((1-Benzyl-1H-indazol-3-yl)oxy)acetic acid

Bendazac is an oxyacetic acid with multiple function, including possessing anti-inflammatory, anti-necrotic, choleretic, and anti-lipidemic characteristics and inhibiting the denaturation of proteins.

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技术信息

生物活性

描述Bendazac is an oxyacetic acid with anti-inflammatory, antinecrotic, choleretic and antilipidaemic properties, but its principal effect is to inhibit the denaturation of proteins^[1]. Bendazac is an anti-inflammatory agent endowed with protein antidenaturant properties effective for various inflammatory skin conditions. Bendazac has been shown to be a strong reacting substrate in a chemical oxidizing system, which mimics a physiological pathway of hydroxy radical generation. Moreover, by means of a rapid and sensitive flow cytometric method able to determine reactive oxygen intermediate production, bendazac and its 5-hydroxy derivative were shown to inhibit oxidative burst activation in polymorphonuclear neutrophil leukocytes (PMNLs)^[2]. Bendazac (bendazac L-lysine and sodium) inhibits the early stages of protein glycation, as well as the formation of fluorescent advanced glycation products. Bendazac lysine (20 mM) proved to be more effective in inhibiting fluorescence development (67% inhibition) that the corresponding sodium salt (35% inhibition). About 40% inhibition was produced with either bendazac lysine or sodium salt bendazac clearly inhibits glycation of human lens crystallins^[3].
参考文献

[1] Balfour JA, Clissold SP. Bendazac lysine. A review of its pharmacological properties and therapeutic potential in the management of cataracts. Drugs. 1990 Apr;39(4):575-96
[2] Guglielmotti A, Capezzone De Joannon A, Cazzolla N, Marchetti M, Soldo L, Cavallo G, Pinza M. Radical scavenger activity of bendazac, an anticataract non-steroidal anti-inflammatory agent. Pharmacol Res. 1995 Dec;32(6):369-73
[3] Marques C, Ramalho JS, Pereira P, Mota MC. Bendazac decreases in vitro glycation of human lens crystallins. Decrease of in vitro protein glycation by bendazac. Doc Ophthalmol. 1995;90(4):395-404

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5424 mL
- 17.7120 mL
- 35.4241 mL
- 5 mM
- 0.7085 mL
- 3.5424 mL
- 7.0848 mL
- 10 mM
- 0.3542 mL
- 1.7712 mL
- 3.5424 mL

技术信息

CAS号

20187-55-7

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H14N2O3

运输

蓝冰

分子量

282.29

别名

bendazolic acid;AF-983;2-((1-Benzyl-1H-indazol-3-yl)oxy)acetic acid;Bindazac;Versus

溶解度

DMSO	54.0 mg/mL (191.3 mM)
Water	Insoluble
Ethanol	54.0 mg/mL (191.3 mM)

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Bendazac/苄达酸 Catalog No. CSN23633

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