|(6R,7R)-7-(2-(3,5-二氯-4-氧代吡啶-1(4H)-基)乙酰氨基)-3-(((5-甲基-1,3,4-噻二唑-2-基)硫基)甲基)-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸|CsnPharm

CAS No.: 56187-47-4

Cefazedone/头孢西酮 Catalog No. CSN21551

Synonyms: Refosporen;Cefazedonum;头孢西酮钠

Cefazedone Sodium a semi-synthetic first-generation cephalosporin with antibacterial activity.

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技术信息

生物活性

描述Cefazedone Sodium, a first-generation cephalosporin, is a time-dependent antibiotic with activity against Gram-positive and Gram-negative bacteria. As a time-dependent antibiotic, the time of cefazedone concentration exceeds the minimum inhibitory concentration (MIC) is the key pharmacokinetic-pharmacodynamic (PK-PD) variable associated with the killing of pathogens. Intravenous injection of cefazodone sodium with 2 g q12 h dosage regimen is used in the treatment of CAP caused by sensitive bacteria, either ƒT > MIC or clinical efficacy shows that such dosing regimen is reasonable^[1]. Cefazedone has a relatively long serum elimination half-life (1.64 +/- 0.23 h after i.v. and 1.85 +/- 0.51 h after i.m. administration) and that cefazedone exhibits, in comparison with cefazolin, a more favourable concentration ratio of central vs. peripheral (= tissue) compartment (1:2)^[2]. The high tissue levels of cefamandole and cefoxitin are especially remarkable as i.v. doses of both antibiotics had been 50 mg/kg body weight (doses of all other cephalosporins 100 mg/kg body weight)^[3].
参考文献

[1] Gao L, Zhu Y, Lyu Y, Hao FL, Zhang P, Wei MJ. A Pharmacokinetic and Pharmacodynamic Study on Intravenous Cefazedone Sodium in Patients with Community-acquired Pneumonia. Chin Med J (Engl). 2015 May 5;128(9):1160-4
[2] Pabst J, Leopold G, Ungethüm W, Dingeldein E. Clinical pharmacology phase I of cefazedone, a new cephalosporin, in healthy volunteers. II. Pharmacokinetics in comparison with cefazolin. Arzneimittelforschung. 1979;29(2a):437-43
[3] Reichart B, Klinner W, Adam D. Antibiotika-Prophylaxe in der Herzchirurgie mit Cephalosporinen [Antibiotic prophylaxis with cephalosporins in heart surgery]. Fortschr Med. 1981 Aug 13;99(30):1159-62. German

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8233 mL
- 9.1167 mL
- 18.2334 mL
- 5 mM
- 0.3647 mL
- 1.8233 mL
- 3.6467 mL
- 10 mM
- 0.1823 mL
- 0.9117 mL
- 1.8233 mL

技术信息

CAS号

56187-47-4

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H15Cl2N5O5S3

运输

蓝冰

分子量

548.44

别名

Refosporen;Cefazedonum;头孢西酮钠

溶解度

DMSO	98.0 mg/mL (178.7 mM)
Water	insoluble

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