|4-(2-(((6R,7R)-2-羧基-7-((Z)-2-(乙氧基亚氨基)-2-(5-(膦酰氨基)-1,2,4-噻二唑-3-基)乙酰胺基)-8-氧代-5-噻-1-氮杂双环[4.2.0]辛-2-烯-3-基)硫代)噻唑-4-基)-1-甲基吡啶-1-醋酸铵|CsnPharm

CAS No.: 400827-46-5

Ceftaroline fosamil/头孢洛林酯 Catalog No. CSN23805

Synonyms: TAK-599;PPI0903;头孢洛林酯

Ceftaroline fosamil is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).

规格	价格	促销价格	库存	数量

400-920-2911

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技术信息

生物活性

描述Ceftaroline fosamil is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). Ceftaroline fosamil is effective against all 10 MRSA isolates used in the dose-ranging studies and requires approximately 17 to 43% fT>MIC (the percentage of time that free drug concentrations remain above the MIC) to produce a 1-log10 kill^[1]. It has been approved by the EMA and FDA for the treatment of adults and children with community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI)^[2]. Ceftaroline fosamil 600 mg given every 12 h was superior to ceftriaxone 2 g given every 24 h for the treatment of Asian patients with PORT III-IV community-acquired pneumonia^[3]. Clinical success rates with ceftaroline fosamil were high in patients with gram-positive osteomyelitis, including those with diabetes or peripheral arterial disease and those with MRSA or MSSA(Methicillin-resistant and methicillin-susceptible Staphylococcus aureus) ^[4].
参考文献

[1] Bhalodi AA, Crandon JL, Biek D, Nicolau DP. Efficacy of ceftaroline fosamil in a staphylococcal murine pneumonia model. Antimicrob Agents Chemother. 2012;56(12):6160-6165
[2] Pani A, Colombo F, Agnelli F, et al. Off-label use of ceftaroline fosamil: A systematic review. Int J Antimicrob Agents. 2019;54(5):562-571
[3] Zhong NS, Sun T, Zhuo C, et al. Ceftaroline fosamil versus ceftriaxone for the treatment of Asian patients with community-acquired pneumonia: a randomised, controlled, double-blind, phase 3, non-inferiority with nested superiority trial. Lancet Infect Dis. 2015;15(2):161-171
[4] Johnson LB, Ramani A, Guervil DJ. Use of Ceftaroline Fosamil in Osteomyelitis: CAPTURE Study Experience. BMC Infect Dis. 2019;19(1):183.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.3428 mL
- 6.7138 mL
- 13.4276 mL
- 5 mM
- 0.2686 mL
- 1.3428 mL
- 2.6855 mL
- 10 mM
- 0.1343 mL
- 0.6714 mL
- 1.3428 mL

技术信息

CAS号

400827-46-5

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H25N8O10PS4

运输

蓝冰

分子量

744.74

别名

TAK-599;PPI0903;头孢洛林酯

溶解度

DMSO	155.0 mg/mL (208.1 mM)
Water	3.29 mg/mL (4.4 mM)

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