生物活性

• 描述Clobetasol propionate is a corticosteroid^[2]. Clobetasol propionate is the most potent of all topical steroids. It is successfully applied in the treatment of various skin diseases such as atopic dermatitis, psoriasis and vulvar lichen sclerosus. Clobetasol propionate exerts anti-inflammatory, immunosuppressive and antimitotic effects influencing the growth, differentiation and function of various cells and inhibiting cytokine production^[3]. Clobetasol propionate (applied topically; daily for 14 days) reduces the epidermal thickness of both normal and psoriatic skin in human psoriatic skin-SCID mouse transplant model topical application^[4]. When compared with calcipotriene/betamethasone dipropionate ointment, clobetasol propionate 0.05% spray produced greater rates of lesion clearance and similar improvement in QOL scores after 2 or 4 weeks of treatment. Clobetasol propionate 0.05% spray is an efficacious and safe treatment for plaque psoriasis and produces significant improvement in QOL for affected patients^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00544687	Healthy	Phase 1	Completed	-	Germany ... more >> bioskin GmbH Hamburg, Germany Collapse <<
  NCT03058744	Psoriasis	Phase 1	Completed	-	United States, California ... more >> Valeant Site 12 Anaheim, California, United States, 92801 Valeant Site 05 Encino, California, United States, 91436 Valeant Site 01 San Diego, California, United States, 92093 Valeant Site 07 Santa Rosa, California, United States, 95401 United States, Florida Valeant Site 10 Orange Park, Florida, United States, 32065 Valeant Site 09 Sanford, Florida, United States, 32771 United States, Georgia Valeant Site 08 Atlanta, Georgia, United States, 30301 United States, Indiana Valeant Site 04 Plainfield, Indiana, United States, 46168 United States, New York Valeant Site 06 New York, New York, United States, 10001 United States, Pennsylvania Valeant Site 11 Philadelphia, Pennsylvania, United States, 19019 United States, Texas Valeant Site 03 Austin, Texas, United States, 73301 Valeant Site 02 Katy, Texas, United States, 77449 Collapse <<
  NCT01166646	Plaque Psoriasis	Phase 2	Completed	-	United States, California ... more >> Therapeutics Clinical Research San Diego, California, United States, 92123 United States, Michigan Michigan Center for Skin Care Research (dba Skin Care Research) Clinton Township, Michigan, United States, 48038 Somerset Skin Centre Troy, Michigan, United States, 48084 United States, North Carolina Dermatology, Laser & Vein Specialists of the Carolinas PLLC Charlotte, North Carolina, United States, 28207 United States, Texas DermResearch Inc. Austin, Texas, United States, 78759 Collapse <<

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• 参考文献

• [1] Hull C, McKeough M, et al. Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: a patient-initiated, double-blind, placebo-controlled pilot trial. J Eur Acad Dermatol Venereol. 2009 Mar;23(3):263-7.

  [2] Feldman SR, Yentzer BA. Topical clobetasol propionate in the treatment of psoriasis: a review of newer formulations. Am J Clin Dermatol. 2009;10(6):397-406

  [3] Pels R, Sterry W, Lademann J. Clobetasol propionate--where, when, why? Drugs Today (Barc). 2008 Jul;44(7):547-57

  [4] Zeigler M, Chi Y, Tumas DB, Bodary S, Tang H, Varani J. Anti-CD11a ameliorates disease in the human psoriatic skin-SCID mouse transplant model: comparison of antibody to CD11a with Cyclosporin A and clobetasol propionate. Lab Invest. 2001 Sep;81(9):1253-61

  [5] Menter MA, Caveney SW, Gottschalk RW. Impact of clobetasol propionate 0.05% spray on health-related quality of life in patients with plaque psoriasis. J Drugs Dermatol. 2012 Nov;11(11):1348-54

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