|Colivelin三氟乙酸盐|CsnPharm

CAS No.: 2803948-60-7

Colivelin TFA/Colivelin三氟乙酸盐 Catalog No. CSN27216

Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro . Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury .

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述STAT3 (signal transducer and activator of transcription protein 3) is a transcription factor, as well as an intracellular signal transducer, activated by cytokines, growth factors, and receptor-or nonreceptor-tyrosine kinases. Colivelin, which activates STAT3 signaling, is a neuroprotective humanin family peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. In wild type C57BL/6 mice, colivelin (1mg/kg; intraperitoneal injection) resulted in improved motor and cognitive function with time, as well as reduced lesion volume suggesting that colivelin protects against ischemic brain injury, and improves neurological outcomes. In ischemic stroke mode, colivelin treatment significantly increased Bielschowsky sliver expressions in the ischemic brain, reduced TUNEL⁺ apoptotic cells and upregulated a bunch of anti-apoptotic genes, suggesting a beneficial effect of colivelin by attenuating neuronal death after brain ischemia. Moreover, STAT3 phosphorylation was elevated in colivelin group as compared to vehicle control, suggesting the activation of STAT3 induced by colivelin. Colivelin treatment mice exhibited enhanced axonal growth compared with vehicle, indicating that colivelin rescued neuronal damage after brain ischemia by improving axonal remodeling which might be associated with STAT3 activation^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.3624 mL
- 1.8122 mL
- 3.6243 mL
- 5 mM
- 0.0725 mL
- 0.3624 mL
- 0.7249 mL
- 10 mM
- 0.0362 mL
- 0.1812 mL
- 0.3624 mL

技术信息

CAS号	2803948-60-7	储存条件	粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C121H207F3N32O37	运输	蓝冰
分子量	2759.13	别名

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Colivelin TFA/Colivelin三氟乙酸盐 Catalog No. CSN27216

靶点选择性

请登录您的专属账户

确认信息