|(S)-2-(2-(3,5-二氟苯基)乙酰胺)-N-((S)-1-甲基-2-氧代-5-苯基-2,3-二氢-1H-苯并[e][1,4]二氮杂杂卓-3-基)丙酰胺|CsnPharm

CAS No.: 209986-17-4

Compound E Catalog No. CSN23874

Synonyms: γ-Secretase-IN-1;GSI-XXI;γ-secretase inhibitor XXI

Compound E is an inhibitor of γ-Secretase.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Compound E is a γ-secretase inhibitor with IC50 value for inhibition of 0.3nM for Aβ production in Chinese hamster ovary cells overexpressing βAPP. Chronic treatment with 10μM Compound E for 7 days led to an increase in full-length presenilin 1 accumulation in SH-SY5Y cells. Also, it blocked Notch S3 and βAPP γ-cleavage at concentration>0.3nM in HEK293 cells stably transfected with βAPP₆₉₅ and mNotchΔE(M1727V) post 16-hour exposure. Oral administration of Compound E at dose of 30mg/kg decreased amyloid β-peptide (1-40) levels in guinea-pig. Combined treatment with 10μM Compound E with 1μM 13-cis RA for 5 days reduced cell number of SH-SY5Y and IMR-32 cells in a time-dependent manner. Compound E combined with hLIF, CHIR-99021 and SB431542 could accelerate the induction of a homogeneous, self-renewing primitive neuroepithelium population from hESCs.
动物研究
剂量
Guinea-pig: 3 mg/kg - 30 mg/kg^[1] (p.o.)

给药途径
p.o.

动物研究
剂量	Guinea-pig: 3 mg/kg - 30 mg/kg^[1] (p.o.)
给药途径	p.o.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0387 mL
- 10.1937 mL
- 20.3873 mL
- 5 mM
- 0.4077 mL
- 2.0387 mL
- 4.0775 mL
- 10 mM
- 0.2039 mL
- 1.0194 mL
- 2.0387 mL

技术信息

CAS号

209986-17-4

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H24F2N4O3

运输

蓝冰

分子量

490.50

别名

γ-Secretase-IN-1;GSI-XXI;γ-secretase inhibitor XXI;ɣ-secretase inhibitor XXI

溶解度

DMSO	95.0 mg/mL (193.7 mM) warming

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Compound E Catalog No. CSN23874

靶点选择性

请登录您的专属账户

确认信息