|N1-(2-(4-甲氧基苯乙烯基)喹唑啉-4-基)-N3,N3-二甲基丙烷-1,3-二胺二盐酸盐|CsnPharm

CAS No.: 1217195-61-3

CP-31398 2HCl Catalog No. CSN20519

Synonyms: CP 31,398 (hydrochloride)

CP-31398 2HCl is a p53 stabilizing agent which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The tumor suppressor p53 plays various functional roles in the cell by regulating multiple regulatory signals that ensure adequate temporal and spatial responses to cellular stress. p53 is usually kept inactive due to ubiquitination by a number of E3 ubiquitin ligases that target p53 for proteasomal degradation^[3].CP-31398, a styrylquinazoline, emerges from a screen for therapeutic agents that restore the wild-type DNA-binding conformation of mutant p53 to suppress tumors in vivo.CC cells treated with CP-31398 or treated with sh-PAX2 inhibited proliferation, invasion, and migration but promoted apoptosis with decreased PAX2 expression. The EMT process in CC cells was also reversed after treatment with CP-31398 or sh-PAX2. Moreover, the tumor formation experiment in nude mice revealed the inhibitory activity of CP-31398 in CC tumor in nude mice by suppressing PAX2^[4].CP-31398 induced growth retardation but the cytotoxic effects were irrelevant to p53 genotype. CP-31398 influenced expression of p53 and the downstream molecules in a cell-dependent manner, but constantly increased p21 expression at the transcriptional level with decreased YY1 expression^[5].The EC cells treated with CP‑31398 or siRNA against MDM2 exhibited an increased apoptosis and a suppressed migration and invasion, corresponding to an increased expression of p53, p21, Bad, Bax, Cyt‑c and caspase‑3, as well as to a decreased expression of Bcl‑2, Cox‑2, MMP‑2 and MMP‑9^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2968 mL
- 11.4840 mL
- 22.9679 mL
- 5 mM
- 0.4594 mL
- 2.2968 mL
- 4.5936 mL
- 10 mM
- 0.2297 mL
- 1.1484 mL
- 2.2968 mL

技术信息

CAS号	1217195-61-3	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C22H28Cl2N4O	运输	蓝冰
分子量	435.39	别名	CP 31,398 (hydrochloride)

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

CP-31398 2HCl Catalog No. CSN20519

靶点选择性

请登录您的专属账户

确认信息