|1-(4-氯苯基)-6,6-二甲基-1,6-二氢-1,3,5-三嗪-2,4-二胺盐酸盐|CsnPharm

CAS No.: 152-53-4

Cycloguanil HCl/盐酸环氯胍 Catalog No. CSN23377

Synonyms: Cycloguanil (hydrochloride);Chloroguanide Triazine;NSC 3074

Cycloguanil HCl is HCl form of cycloguanil which is a metabolite of proguanil and a dihydrofolate reductase inhibitor.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Cycloguanil HCl, the active metabolite of proguanil, is a dihydrofolate-reductase (DHFR) inhibitor and acts on malaria schizonts in erythrocytes and hepatocytes. A partial cross-resistance between pyrimethamine and cycloguanil that is based on similar amino acid substitutions in dihydrofolate reductase and suggest that two or three mutations, including at least Asn-108, may be necessary for cycloguanil resistance, whereas a single Asn-108 mutation is sufficient for pyrimethamine resistance^[1]. The combination of atovaquone and cycloguanil yielded corresponding mean sigmaFICs of 3.70 and 2.11, indicating antagonism. The EC50 and EC90 values for proguanil alone were not influenced by RPMI-1640 medium with low concentrations of paraaminobenzoic acid and folic acid (LPLF culture medium), whereas the EC50 and EC90 values for cycloguanil were more than 10 times lower in LPLF medium than in normal RPMI-1640 medium^[2]. Cycloguanil (2.5 micrograms/ml) combined with a noninhibitory concentration of sulfadiazine (25 micrograms/ml) inhibited T. gondii more than cycloguanil alone^[3].
参考文献

[1] Basco LK, Ringwald P. Molecular epidemiology of malaria in Yaounde, Cameroon. VI. Sequence variations in the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene and in vitro resistance to pyrimethamine and cycloguanil. Am J Trop Med Hyg. 2000 Feb;62(2):271-6
[2] Thapar MM, Gupta S, Spindler C, Wernsdorfer WH, Björkman A. Pharmacodynamic interactions among atovaquone, proguanil and cycloguanil against Plasmodium falciparum in vitro. Trans R Soc Trop Med Hyg. 2003 May-Jun;97(3):331-7
[3] Holfels E, McAuley J, Mack D, Milhous WK, McLeod R. In vitro effects of artemisinin ether, cycloguanil hydrochloride (alone and in combination with sulfadiazine), quinine sulfate, mefloquine, primaquine phosphate, trifluoperazine hydrochloride, and verapamil on Toxoplasma gondii. Antimicrob Agents Chemother. 1994 Jun;38(6):1392-6

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4701 mL
- 17.3505 mL
- 34.7010 mL
- 5 mM
- 0.6940 mL
- 3.4701 mL
- 6.9402 mL
- 10 mM
- 0.3470 mL
- 1.7350 mL
- 3.4701 mL

技术信息

CAS号

152-53-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C11H15Cl2N5

运输

蓝冰

分子量

288.18

别名

Cycloguanil (hydrochloride);Chloroguanide Triazine;NSC 3074;AI3-26080;BN 2410;Cycloguanil HCl;环氯胍盐酸盐

溶解度

DMSO	100.0 mg/mL (347.0 mM)
Water	11.5 mg/mL (39.9 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Cycloguanil HCl/盐酸环氯胍 Catalog No. CSN23377

靶点选择性

请登录您的专属账户

确认信息