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CAS No.: 352458-37-8

Delafloxacin meglumine/德拉沙星葡甲胺 Catalog No. CSN15796

Synonyms: ABT492 meglumine;RX-3341 meglumine;WQ-3034 meglumine

Delafloxacin meglumine is a fluoroquinolone antibiotic agent.

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技术信息

生物活性

描述Delafloxacin meglumine is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia. Delafloxacin (the total daily doses vary from 0.156 to 640 mg/kg/24 h, subcutaneous injection) is highly effective against S. aureus. Against all four strains are observed a decrease of 1.5 to 2.2 log10 CFU in organism burden from untreated controls at even the lowest dose studied, and for two strains (MW2 and R2527) there is net bactericidal activity at the lowest dose. At the maximal doses studied, there is a >4-log10 kill from initial burden for all S. aureus strains^[2]. Delafloxacin meglumine is used for the treatment of acute bacterial skin and skin structure infections on the basis of data from two phase III trials. Delafloxacin is administered via both oral and parenteral routes. It has potent activity against methicillin-resistant Staphylococcus aureus and Streptococci, and is also effective against Enterobacteriaceae and Pseudomonas aeruginosa^[3].
参考文献

[1] Gunderson SM, Hayes RA, et al. In vitro pharmacodynamic activities of ABT-492, a novel quinolone, compared to those of levofloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Antimicrob Agents Chemother. 2004 Jan;48(1):203-8.
[2] Lepak AJ, Andes DR. In Vivo Pharmacodynamic Target Assessment of Delafloxacin against Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumoniae in a Murine Lung Infection Model. Antimicrob Agents Chemother. 2016;60(8):4764‐4769.
[3] Kaul G, Kapoor E, Dasgupta A, Chopra S. Delafloxacin meglumine for the treatment of acute bacterial skin and skin structure infections (ABSSSI). Drugs Today (Barc). 2018;54(11):657‐666

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5724 mL
- 7.8620 mL
- 15.7239 mL
- 5 mM
- 0.3145 mL
- 1.5724 mL
- 3.1448 mL
- 10 mM
- 0.1572 mL
- 0.7862 mL
- 1.5724 mL

技术信息

CAS号

352458-37-8

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C25H29ClF3N5O9

运输

蓝冰

分子量

635.97

别名

ABT492 meglumine;RX-3341 meglumine;WQ-3034 meglumine;Delafloxacin (meglumine);ABT-492;RX-3341;WQ-3034;Baxdela;德拉沙星葡甲胺

溶解度

DMSO	42.0 mg/mL (66.0 mM)
Water	3.71 mg/mL (5.8 mM)

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