Dihydrochelerythrine is a natural product isolated and purified from the herbs of Chelidonium majus, has antifungal activity against pathogenic plant fungi., and shows antiparasitic efficacy against Ichthyophthirius multifiliis in richadsin. Dihydrochelerythrine also affects cell cycle distribution, activates mitochondrial apoptotic pathway, and induces apoptosis and necrosis in HL-60 cells.
Dihydrochelerythrine is a natural compound isolated from the leaves of Macleaya microcarpa, and has antifungal activity. Dihydrochelerythrine showed the highest antifungal activity against B. cinerea Pers, with 98.32% mycelial growth inhibition at 50 μg/mL. Dihydrochelerythrine inhibited spore germination in vitro in a concentration-dependent manner[3]. Dihydrochelerythrine exhibited strong activity against methicillin-resistant Staphylococcus aureus SK1 and moderate activity against Escherichia coli TISTR 780 with MIC values of 8 and 16 μg/mL, respectively[4]. After 4h of treatment, chelerythrine induced a dose-dependent decrease in the cell viability (human promyelocytic leukemia HL-60 cells) with IC50 of 2.6 microM as shown by MTT reduction assay. Dihydrochelerythrine can affect cell cycle distribution, activate mitochondrial apoptotic pathway, and induce apoptosis and necrosis in HL-60 cells[5].
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