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CAS No.: 125-02-0

Disodium Prednisolone 21-Phosphate/泼尼松龙21-磷酸二钠 Catalog No. CSN11768

Synonyms: Prednisolone 21-phosphate disodium;Hydeltrasol;Prednisolone Phosphate Sodium

Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

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技术信息

生物活性

描述Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. It is hydrolyzed to prednisolone in vivo. Prednisolone phosphate (10 mg/kg), administered in long-circulating liposomes, decreases inflammation and the levels of IL-1β in the synovium, as well as reduces damage to the cartilage matrix in a mouse model of antigen-induced arthritis^[3]. It also reduces tumor growth in B16/F10 melanoma and C26 colon carcinoma mouse models when administered in long-circulating liposomes at a dose of 20 mg/kg^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00241982	Rheumatoid Arthritis	Phase 2	Completed	-	Netherlands ... more >> Radboud University Nijmegen Medical Centre Nijmegen, Gelderland, Netherlands, 6500 HB Collapse <<

参考文献

[1] Lambrou GI, Vlahopoulos S, et al. Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res. 2009 Dec;33(12):1684-95.
[2] Matts SG. A comparison of sustained-release prednisolone disodium phosphate with prednisolone in the treatment of reversible bronchospasm. Br J Clin Pract. 1972 Sep;26(9):418-20.
[3] Hofkens W, Storm G, van den Berg WB, van Lent PL. Liposomal targeting of glucocorticoids to the inflamed synovium inhibits cartilage matrix destruction during murine antigen-induced arthritis. Int J Pharm. 2011;416(2):486-492.
[4] Schiffelers RM, Metselaar JM, Fens MH, Janssen AP, Molema G, Storm G. Liposome-encapsulated prednisolone phosphate inhibits growth of established tumors in mice. Neoplasia. 2005 Feb;7(2):118-27.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0645 mL
- 10.3223 mL
- 20.6446 mL
- 5 mM
- 0.4129 mL
- 2.0645 mL
- 4.1289 mL
- 10 mM
- 0.2064 mL
- 1.0322 mL
- 2.0645 mL

技术信息

CAS号

125-02-0

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H27Na2O8P

运输

蓝冰

分子量

484.39

别名

Prednisolone 21-phosphate disodium;Hydeltrasol;Prednisolone Phosphate Sodium;Prednisolone Phosphate (sodium salt);Disodium Prednisolone 21-Phosphate;Prednisolone Sodium Phosphate;泼尼松龙21-磷酸二钠

溶解度

Water

50.0 mg/mL (103.2 mM) warming

动物实验配方

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Disodium Prednisolone 21-Phosphate/泼尼松龙21-磷酸二钠 Catalog No. CSN11768

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