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CAS No.: 1219168-18-9

Dorsomorphin 2HCl Catalog No. CSN15887

Synonyms: Compound C dihydrochloride;BML-275 dihydrochloride;BML-275 2HCl

Dorsomorphin 2HCl is a selective AMPK inhibitor with Ki value of 109 nM.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 AMPK

Ki:109nM
描述Dorsomorphin dihydrochloride is the dihydrochloride form of dorsomorphin. Dorsomorphin, known as compound C, is a reversible selective ATP-competitive inhibitor of AMPK with Ki of 109 nM. Dorsomorphin can also inhibit the bone morphogenic protein (BMP) signaling and do not effect the expression of several structurally related kinases including ZAPK, SYK, PKCq, PKA, and JAK3^[3]. In addition, dorsomorphin could stimulate the oxidation of long chain fatty acids independently in adipocytes by increasing carnitine palmitoyltransferase-1 (CPT1) activity^[4] and remarkly reduce the adipogenic Differentiation of 3T3-L1 cells at 10 μM^[5]. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway^[6]. In vivo, dorsomorphin induces dorsalization in zebrafish embryos and the differentiation of osteoblast^[7].
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
mouse C2C12 cells	4 μM	Function assay	-	Inhibition of BMPR1-mediated osteoblast differentiation in BMP4-stimulated mouse C2C12 cells assessed as decrease in alkaline phosphatase level at 4 uM by spectrophotometry	18026094

动物研究
剂量
Mice: 3 mg/kg - 12 mg/kg^[3] (i.p.)
Rat: 0.2 mg/kg^[4] (i.v.)

给药途径
i.p., i.v.

动物研究
剂量	Mice: 3 mg/kg - 12 mg/kg^[3] (i.p.) Rat: 0.2 mg/kg^[4] (i.v.)
给药途径	i.p., i.v.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1168 mL
- 10.5840 mL
- 21.1680 mL
- 5 mM
- 0.4234 mL
- 2.1168 mL
- 4.2336 mL
- 10 mM
- 0.2117 mL
- 1.0584 mL
- 2.1168 mL

技术信息

CAS号

1219168-18-9

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H27Cl2N5O

运输

蓝冰

分子量

472.41

别名

Compound C dihydrochloride;BML-275 dihydrochloride;BML-275 2HCl;Compound C 2HCl;Dorsomorphin (hydrochloride);BML-275;Compound C;CpdC;Dorsomorphin HCl

溶解度

DMSO	Insoluble
Water	50.0 mg/mL (105.8 mM)

动物实验配方

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