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CAS No.: 88321-09-9

E-64d/阿洛司他丁 Catalog No. CSN16047

Synonyms: E64d;E64c ethyl ester;EP 453

Aloxistatin is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity.

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技术信息

生物活性

描述Cysteine proteases play multiple roles in basically all aspects of physiology and development. Furthermore, they are engaged in signalling pathways and in the response to biotic and abiotic stresses^[3]. Aloxistatin is a specific and potent inhibitor of cysteine proteinases isolated from a culture of Aspergillus japonicus^[3]. Aloxistatin at a series of concentrations was able to enter the intact platelet and inhibit the protease activity in lysed platelets when incubated for 5 min^[4]. After a brief preincubation with the membrane-permeable, Aloxistatin (10 mg/ml) blunted PTH-induced (parathyroid hormone) cell proliferation in sub-confluent cultures and also attenuated proliferation and inhibited differentiation in longer-term confluent cultures^[5]. Aloxistatin(100 mg/kg, p.o.) inhibited the activity of cathepsin B&L in skeletal muscle, heart, and liver of hamsters^[6].
作用机制Aloxistatin reacts irreversibly with the thiol group at the active site.
细胞研究
Cell Data
Cell Lines Concentration Assay Type Time Activity Description Data Sources
U937 cells - Function assay - Blockade of cathepsin G processing in human U937 cells by densitometry, IC50=1.1 μM 17535802

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
U937 cells	-	Function assay	-	Blockade of cathepsin G processing in human U937 cells by densitometry, IC50=1.1 μM	17535802

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9203 mL
- 14.6015 mL
- 29.2030 mL
- 5 mM
- 0.5841 mL
- 2.9203 mL
- 5.8406 mL
- 10 mM
- 0.2920 mL
- 1.4602 mL
- 2.9203 mL

技术信息

CAS号

88321-09-9

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H30N2O5

运输

蓝冰

分子量

342.43

别名

E64d;E64c ethyl ester;EP 453;EST;Loxistatin;ethyl ester Loxistatin;NSC-694281

溶解度

DMSO	600.0 mg/mL (1752.2 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	6 mg/mL	clear
PO	0.5% CMC-Na	36 mg/mL	suspension

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