CAS No.: 226954-04-7
Emapunil Catalog No. CSN18136
Synonyms: AC-5216;XBD-173
Emapunil is a ligand of translocator protein TSPO (18 kDa) with Ki of 0.297 nM. It can enhance GABA-mediated neurotransmission via induction of neurosteroidogenesis and has antidepressant effect.
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纯度 & 质量文件
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生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02181582 Baseline Bloc... more >>king Receptor Binding Collapse << Phase 1 Completed - United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << NCT02086240 Neurodegenerative Disorders Not Applicable Unknown May 2017 United Kingdom ... more >> NIHR/Wellcome Trust Imperial Clinical Research Facility Recruiting London, United Kingdom, W12 0HS Contact: Dimitra Kalogiannopoulou +44(0)2033138063 d.kalogiannopoulou11@imperial.ac.uk Principal Investigator: David Owen Collapse << - 参考文献
- [1] Qiu ZK, Zhang LM, et al. Repeated administration of AC-5216, a ligand for the 18 kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:40-6.
- [2] Kita A, Kohayakawa H, et al. Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. Br J Pharmacol. 2004 Aug;142(7):1059-72.
实验方案
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技术信息
| CAS号 | 226954-04-7 | 储存条件 |
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| 分子式 | C23H23N5O2 | 运输 | 蓝冰 | |||
| 分子量 | 401.46 | 别名 | AC-5216;XBD-173 | |||
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动物实验配方 |
