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FEN1-IN-3 98%+

货号：A605561 同义名： FEN1 Inhibitor C3 产品仅供科研

FEN1 inhibitor C3 is an inhibitor of flap endonuclease 1 (FEN1) which is required for proficient DNA replication and the repair of DNA damage.

FEN1-IN-3 化学结构 CAS号：2109805-87-8
FEN1-IN-3 化学结构
CAS号：2109805-87-8
FEN1-IN-3 3D分子结构
CAS号：2109805-87-8
FEN1-IN-3 化学结构 CAS号：2109805-87-8
FEN1-IN-3 3D分子结构 CAS号：2109805-87-8
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FEN1-IN-3 纯度/质量文件

货号：A605561 标准纯度：98%+
批次查询： 批次纯度:

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产品名称 DNA synthesis ↓ helicase ↓ RdRp ↓ ribonucleotide reductase ↓ tRNA synthetase ↓ YB-1 ↓ 其他靶点 纯度
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Daptomycin ✔ 98%
Blasticidin S HCl ✔ 99%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

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Triglycidyl isocyanurate ✔ p53 98+%
Nedaplatin ✔ 99%+
Bendamustine ✔ 99%+
Trifluridine ✔ 98%
Robinetin ✔ 99%+
Carboplatin ✔ 99%
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Cisplatin ✔ 99%
Cytarabine ++++

DNA synthesis, IC50: 16 nM

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Acelarin ++++

DNA synthesis, EC50: 0.2 nM

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Oxaliplatin ✔ 98%
YK-4-279 ✔ 99%+
ML216 +

BLM636-1298, IC50: 0.97 μM

BLMfull-length, IC50: 2.98 μM

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RK-33 ✔ 99%+
Brr2-IN-3 ✔ 99%+
Phen-DC3 Trifluoromethanesulfonate ✔ 98%
Favipiravir ✔ 97%
Suramin sodium salt ++

RdRp, IC50: 0.26 μM

 		99%+
Clofarabine ++

Ribonucleotide reductase, IC50: 65 nM

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Didox ✔ 99%+
(E)-3-AP ✔ 97%
Halofuginone +++

prolyl-tRNA synthetase, Ki: 18.3nM

 		99%+
BC-LI-0186 +++

Leucyl-tRNA synthetase, IC50: 46.11 nM

Leucyl-tRNA synthetase, Kd: 42.1 nM

 		98%
SU056 +

YB-1, IC50: 1.73 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

FEN1-IN-3 生物活性

描述 The structure-selective human flap endonuclease-1 (FEN1) is a metallonuclease that plays a key role in DNA replication and genome maintenance. Human FEN1 is overexpressed in multiple cancer types and therefore has been suggested as an oncology target. FEN1 inhibitor C3 stabilizes human FEN1 with an EC50 value of 6.8μM in an isothermal concentration-response experiment. FEN1 inhibitor C3 inhibits human FEN1-336Δ with an IC50 value of 16.9±1.2nM. It also exhibited cytotoxic against HeLa cells with an EC50 value of 6μM[2].

FEN1-IN-3 参考文献

[1]Ward TA, McHugh PJ, Durant ST. Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One. 2017 Jun 19;12(6):e0179278.

[2]Exell JC, Thompson MJ, Finger LD, et al. Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat Chem Biol. 2016;12(10):815-821.

FEN1-IN-3 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.59mL

3.52mL

1.76mL

35.18mL

7.04mL

3.52mL

FEN1-IN-3 技术信息

CAS号2109805-87-8
分子式C15H12N2O4
分子量284.267
别名 FEN1 Inhibitor C3
运输蓝冰
存储条件

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 250 mg/mL(879.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: FEN1-IN-3 | 2109805-87-8 | FLAP | 5-lipoxygenase-activating protein | FEN1 Inhibitor | Immunology/Inflammation | FLAP | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | FEN1-IN-3 纯度/质量文件 | FEN1-IN-3 亚型比较 | FEN1-IN-3 生物活性 | FEN1-IN-3 参考文献 | FEN1-IN-3 实验方案 | FEN1-IN-3 技术信息

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