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CAS No.: 1707289-21-1

Fisogatinib Catalog No. CSN18780

Synonyms: BLU-554

BLU-554 is a selective inhibitor of FGFR4 with the IC50 of 5 nM.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The fibroblast growth factor receptor 4 (FGFR4) is a member of the tyrosine kinase receptor family. BLU-554 is a potent, selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50 values of BLU-554 for FGFR1, 2, and 3 are 624, 1202, and 2203 nM, respectively. In animals bearing Hep3B xenograft tumors, the treatment with BLU-554 at 100 mg/kg (b.i.d., p.o.) and 200 mg/kg (q.d., p.o.) for 20 days completed inhibited tumor growth compared to the vehicle control group. In the LIX-066 model, BLU-554 at 30 – 100 mg/kg (b.i.d., p.o.) suppressed tumor growth at 20-day post-treatment.
作用机制BLU-554 is a potent and highly selective FGFR4 inhibitor that covalently binds to FGFR4.
临床研究
NCT号适应症或疾病临床期招募状态预计完成时间地点
NCT02508467 Hepatocellular Carcinoma (HCC) Phase 1 Recruiting August 2020 -

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02508467	Hepatocellular Carcinoma (HCC)	Phase 1	Recruiting	August 2020	-

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9866 mL
- 9.9329 mL
- 19.8657 mL
- 5 mM
- 0.3973 mL
- 1.9866 mL
- 3.9731 mL
- 10 mM
- 0.1987 mL
- 0.9933 mL
- 1.9866 mL

技术信息

CAS号

1707289-21-1

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H24Cl2N4O4

运输

蓝冰

分子量

503.38

别名

BLU-554

溶解度

DMSO	100 mg/ml (198.66 mM)
Water	Insoluble

动物实验配方

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