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CAS No.: 2135-17-3

Flumetasone/氟米松 Catalog No. CSN11027

Synonyms: Flumetasone;RS-2177;NSC 54702

Flumethasone is a corticosteroid mainly used in combination with clioquinol to treat otomycosis and otitis externa.

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技术信息

生物活性

描述Flumethasone is a corticosteroid for topical use, in combination with Clioquinol for the treatment of otitis externa and otomycosis. Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity. Flumethasone, a glucocorticoid, inhibited Nrf2 (Nuclear factor erythroid-2-related factor 2) signaling in A549 and H460 cells by promoting Nrf2 protein degradation. Moreover, flumethasone significantly increased the sensitivity of A549 and H460 cells to chemotherapeutic drugs including cisplatin, doxorubicin and 5-FU. Flumethasone can potentially be used as an adjuvant sensitizer to enhance the efficacy of chemotherapeutic drugs in lung cancer^[3]. Administration of flumethasone (3.5 mg i.m.) to six cows on day 260 of pregnancy induced parturition in only one animal. In the other five cows circulating concentrations of epitestosterone and conjugated oestrogens increased to reach maximum values (epitestosterone, 13.73 +/- 2.81 nmol/l; conjugated oestrogens, 33.59 +/- 6.87 nmol/l) 2-3 days after treatment. Concentrations of these steroids were raised as long as the synthetic glucocorticoid was present in the circulation (as judged by depression of cortisol concentrations)^[4].
参考文献

[1] Sternbauer K, Luthman J, et al. Flumethasone-induced insulin resistance in calves. Zentralbl Veterinarmed A. 1998 Sep;45(6-7):441-3.
[2] Sustronck B, Deprez P, et al. Efficacy of the combination sodium ceftiofur-flumethasone in the treatment of experimental Pasteurella haemolytica bronchopneumonia in calves. Zentralbl Veterinarmed A. 1997 May;44(3):179-87.
[3] Zhou Y, Zhou Y, Wang K, Li T, Yang M, Wang R, Chen Y, Cao M, Hu R. Flumethasone enhances the efficacy of chemotherapeutic drugs in lung cancer by inhibiting Nrf2 signaling pathway. Cancer Lett. 2020 Apr 1;474:94-105
[4] Möstl E, Choi HS, Bamberg E. Stimulation of androgen and oestrogen concentrations in plasma of cows after administration of a synthetic glucocorticoid (flumethasone) at the end of gestation. J Endocrinol. 1985 Apr;105(1):121-6

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4363 mL
- 12.1817 mL
- 24.3634 mL
- 5 mM
- 0.4873 mL
- 2.4363 mL
- 4.8727 mL
- 10 mM
- 0.2436 mL
- 1.2182 mL
- 2.4363 mL

技术信息

CAS号

2135-17-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H28F2O5

运输

蓝冰

分子量

410.45

别名

Flumetasone;RS-2177;NSC 54702;NSC 5402;U-10974;U-10,974;Anaprime;Aniprime;Fluvet;Methagon;BRN 5645455;Cortexilar;Flucort;Flucorticin;Locacorten;Locorten;氟米松

溶解度

DMSO	81.0 mg/mL (197.3 mM)
Water	Insoluble
Ethanol	6.0 mg/mL (14.6 mM)

动物实验配方

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Flumetasone/氟米松 Catalog No. CSN11027

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