|1-(3-氟苯基)-5-甲基吡啶-2(1H)-酮|CsnPharm

CAS No.: 848353-85-5

Fluorofenidone Catalog No. CSN25216

Synonyms: AKF-PD

Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and ECM deposition via the PI3K/Akt signalling pathway, suggesting AKF-PD is a potential novel therapeutic agent against renal fibrosis.

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技术信息

生物活性

描述Oxidative stress plays an important role in the progression of renal interstitial fibrosis. The nicotinamide adeninedinucleotide phosphate (NADPH) oxidase (Nox) family is considered one of the major sources of reactive oxygen species (ROS)^[1]. Fluorofenidone is an effective and novel antifibrotic agent with an IC₅₀ value of 4.18 mM^[2]. Fluorofenidone treatment significantly attenuated tubulo-interstitial injury, ECM deposition and oxidative stress in fibrotic rat kidneys. In addition, Fluorofenidone inhibited the expression of ROS, Collagen I (1a), Nox2, p-Akt in Ang II-stimulated NRK-52E cells. Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and ECM deposition via the PI3K/Akt signalling pathway, suggesting Fluorofenidone is a potential and novel therapeutic agent against renal fibrosis^[1].
参考文献

[1] Qin J, Xie YY, Huang L, Yuan QJ, Mei WJ, Yuan XN, Hu GY, Cheng GJ, Tao LJ, Peng ZZ. Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Nephrology (Carlton). 2013 Oct;18(10):690-9. doi: 10.1111/nep.12128. PMID: 23841831.
[2] Lou Q, Meng X, Lao Z, Xuan L, Bai J, Hou Q, Hu G, Luo R, Tao L, Li Z. Design, synthesis and antifibrotic activities of carbohydrate-modified 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones. Molecules. 2012 Jan 17;17(1):884-96. doi: 10.3390/molecules17010884. PMID: 22252504; PMCID: PMC6269014.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.9210 mL
- 24.6048 mL
- 49.2096 mL
- 5 mM
- 0.9842 mL
- 4.9210 mL
- 9.8419 mL
- 10 mM
- 0.4921 mL
- 2.4605 mL
- 4.9210 mL

技术信息

CAS号

848353-85-5

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H10FNO

运输

蓝冰

分子量

203.21

别名

AKF-PD

溶解度

DMSO	58.75 mg/mL (289.1 mM)
Water	insoluble

动物实验配方

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