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CAS No.: 1337531-36-8
Synonyms: GSK PERK Inhibitor
GSK2606414 is an orally available, potent, and selective PERK inhibitor with an IC50 of 0.4 nM.
生物活性
靶点 | PERK IC50:0.4nM |
动物研究 | |||||||||||||||||||||||||||||
剂量 | Mice: 0.25 mg/kg - 5 mg/kg[2] (i.p.); 50 mg/kg - 150 mg/kg[3] (p.o.) | ||||||||||||||||||||||||||||
给药途径 | i.p., p.o. | ||||||||||||||||||||||||||||
动物药代数据 |
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实验方案
技术信息
CAS号 | 1337531-36-8 | 储存条件 |
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分子式 | C24H20F3N5O | 运输 | 蓝冰 | |||||||||||||
分子量 | 451.44 | 别名 | GSK PERK Inhibitor | |||||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human A549 cells | - | Function assay | 2 h | Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells after 2 hrs by Western blotting | 22827572 |
human A549 cells | 0.03 μM | Function assay | 2 h | Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells at 0.03 uM after 2 hrs by Western blotting | 22827572 |
human A549 cells | - | Function assay | 1 h | Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells preincubated for 1 hr followed by thapsigargin-induction measured after 1 hr by Western blotting analysis | 24900593 |
靶点 | Description | IC50 |
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PERK | IC50:0.4nM |
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