CAS No.: 210354-22-6
GW274150 Catalog No. CSN18103
GW274150 is an arginine-competitive, NADPH-dependent iNOS inhibitor that has been identified from a series of acetamide amino acids that have a high selectivity for iNOS vs both eNOS (> 260-fold) and nNOS (> 219-fold) and high bioavailability (> 90%) after oral administration.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00379990 Arthritis, Rheumatoid Phase 2 Completed - Serbia ... more >> GSK Investigational Site Belgrade, Serbia, 11000 United Kingdom GSK Investigational Site London, United Kingdom, W6 8LH Collapse << NCT00273013 Asthma Phase 1 Completed - United Kingdom ... more >> GSK Investigational Site Manchester, Lancashire, United Kingdom, M23 9LT GSK Investigational Site London, United Kingdom, SE1 9RT Collapse << NCT00370435 Arthritis, Rheumatoid Phase 2 Completed - United Kingdom ... more >> GSK Investigational Site London, United Kingdom, W6 8LH Collapse << - 更多
- 参考文献
- [1] Seymour M, Petavy F, et al. Ultrasonographic measures of synovitis in an early phase clinical trial: a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis. Clin Exp Rheumatol. 2012 Mar-Apr;30(2):254-61.
- [2] Broom L, Marinova-Mutafchieva L, et al. Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease. Free Radic Biol Med. 2011 Mar 1;50(5):633-40.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 210354-22-6 | 储存条件 |
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| 分子式 | C8H17N3O2S | 运输 | 蓝冰 | |
| 分子量 | 219.30 | 别名 |
