生物活性

• 描述Halobetasol propionate is a synthetic corticosteroid for topical dermatological use; exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties. Halobetasol propionate (HP) is an effective short-term superpotent TCS (superpotent topical corticosteroids)^[3]. Halobetasol propionate was distinctly more potent than clobetasol 17-propionate in the ultraviolet-induced dermatitis inhibition assay in guinea pigs and in the rat model of oxazolone-induced late inflammatory reaction. Halobetasol propionate was slightly more potent than clobetasol 17-propionate in inhibiting croton oil-induced ear edema in rats and mice and in the mouse model of oxazolone-induced early inflammatory reaction. In the cotton-pellet granuloma assay in rats and the epidermal hyperplasia inhibition assay in guinea pigs, halobetasol propionate was distinctly superior to clobetasol 17-propionate^[4]. HP lotion was associated with significant reductions in disease severity in male and female participants with moderate-to-severe psoriasis, with good tolerability and safety over 8 weeks of once-daily use^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00234728	Psoriasis	Not Applicable	Completed	-	United States, California ... more >> UCSF Psoriasis and Skin Treatment Center San Francisco, California, United States, 94118 Collapse <<
  NCT02045277	Plaque Psoriasis	Phase 2	Completed	-	United States, California ... more >> Valeant Site 13 Encino, California, United States, 91436 Valeant Site 11 San Diego, California, United States, 92123 Valeant Site 15 Santa Rosa, California, United States, 95403 United States, Georgia Valeant Site 10 Augusta, Georgia, United States, 30909 Valeant Site 09 Newnan, Georgia, United States, 30263 United States, Kentucky Valeant Site 08 Louisville, Kentucky, United States, 40217 United States, Maryland Valeant Site 04 Rockville, Maryland, United States, 20850 United States, Michigan Valeant Site 14 Clinton Township, Michigan, United States, 48038 United States, Minnesota Valeant Site 07 Fridley, Minnesota, United States, 55432 United States, New Jersey Valeant Site 01 East Windsor, New Jersey, United States, 08520 United States, New York Valeant Site 03 New York, New York, United States, 10075 Valeant Site 17 Rochester, New York, United States, 14623 United States, North Carolina Valeant Site 02 High Point, North Carolina, United States, 27262 United States, Texas Valeant Site 05 Austin, Texas, United States, 78759 Valeant Site 06 College Station, Texas, United States, 77845 United States, Utah Valeant Site 16 Salt Lake City, Utah, United States, 84117 United States, Virginia Valeant Site 18 Lynchburg, Virginia, United States, 24501 Valeant Site 12 Norfolk, Virginia, United States, 23507 Collapse <<
  NCT02514577	Plaque Psoriasis	Phase 3	Completed	-	United States, Arkansas ... more >> Valeant Site 11 Hot Springs, Arkansas, United States, 71901 United States, California Valeant Site 1 Encinitas, California, United States, 92023 Valeant Site 10 Encino, California, United States, 91436 Valeant Site 12 Santa Rosa, California, United States, 95401 United States, Georgia Valeant Site 13 Atlanta, Georgia, United States, 30301 United States, Idaho Valeant Site 7 Boise, Idaho, United States, 83701 United States, Maryland Valeant Site 6 Rockville, Maryland, United States, 20847 United States, Michigan Valeant Site 4 Ann Arbor, Michigan, United States, 48103 Valeant Site 8 Clarkston, Michigan, United States, 48346 United States, Nevada Valeant Site 15 Las Vegas, Nevada, United States, 89101 United States, North Carolina Valeant Site 9 Raleigh, North Carolina, United States, 27601 United States, Tennessee Valeant Site 5 Knoxville, Tennessee, United States, 37901 United States, Texas Valeant Site 3 Austin, Texas, United States, 73301 Valeant Site 2 San Antonio, Texas, United States, 78201 United States, Washington Valeant Site 14 Spokane, Washington, United States, 99201 Collapse <<

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• 参考文献

• [1] Mohandas S, Rai R, et al. Halobetasol versus clobetasol: a study of potency. Indian J Dermatol Venereol Leprol. 2009 Mar-Apr;75(2):186-7.

  [2] Kantor I, Cook PR, et al. Double-blind bilateral paired comparison of 0.05% halobetasol propionate cream and its vehicle in patients with chronic atopic dermatitis and other eczematous dermatoses. J Am Acad Dermatol. 1991 Dec;25(6 Pt 2):1184-6.

  [3] Bagel J, Thibodeaux QG, Han G. Halobetasol propionate for the management of psoriasis. Cutis. 2020 Feb;105(2):92-96;E4

  [4] Yawalkar S, Wiesenberg-Boettcher I, Gibson JR, Siskin SB, Pignat W. Dermatopharmacologic investigations of halobetasol propionate in comparison with clobetasol 17-propionate. J Am Acad Dermatol. 1991 Dec;25(6 Pt 2):1137-44

  [5] Cook-Bolden FE, Hebert AA, Guenthner ST, Kang R, Martin G, Jacobson A. Halobetasol Propionate Lotion 0.01% for Moderate-to-Severe Plaque Psoriasis: Pooled Analysis in Male and Female Participants. J Drugs Dermatol. 2020 Aug 1;19(8):747-754

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