CAS No.: 186611-52-9
IC261 Catalog No. CSN18054
Synonyms: SU-5607
IC261 is an ATP-competitive inhibitor of CK1 with IC50s about 1 μM for CK1δ and CK1ε, 16 μM for CK1α.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 作用机制
动物研究 剂量 Mice: 30 mg/kg[4] (i.p.)
给药途径 i.p.
- 参考文献
- [1] Chia R, Haddock S, et al. Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nat Commun. 2014 Dec 15;5:5827.
- [2] Behrend L, Milne DM, et al. IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Oncogene. 2000 Nov 9;19(47):5303-13.
- [3] Mashhoon N, DeMaggio AJ, et al. Crystal structure of a conformation-selective casein kinase-1 inhibitor. J Biol Chem. 2000 Jun 30;275(26):20052-60.
- [4] Mashhoon N, DeMaggio AJ, Tereshko V, Bergmeier SC, Egli M, Hoekstra MF, Kuret J. Crystal structure of a conformation-selective casein kinase-1 inhibitor. J Biol Chem. 2000 Jun 30;275(26):20052-60. doi: 10.1074/jbc.M001713200. PMID: 10749871.
- [5] Chia R, Haddock S, Beilina A, Rudenko IN, Mamais A, Kaganovich A, Li Y, Kumaran R, Nalls MA, Cookson MR. Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nat Commun. 2014 Dec 15;5:5827. doi: 10.1038/ncomms6827. PMID: 25500533; PMCID: PMC4268884.
- [6] Behrend L, Milne DM, Stöter M, Deppert W, Campbell LE, Meek DW, Knippschild U. IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Oncogene. 2000 Nov 9;19(47):5303-13. doi: 10.1038/sj.onc.1203939. PMID: 11103931.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 186611-52-9 | 储存条件 |
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| 分子式 | C18H17NO4 | 运输 | 蓝冰 | |||||||
| 分子量 | 311.33 | 别名 | SU-5607 | |||||||
| 溶解度 |
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动物实验配方 |
