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CAS No.: 482-44-0

Imperatorin/欧前胡素 Catalog No. CSN16369

Synonyms: Ammidin;Marmelosin;Pentosalen

Imperatorin is a naturally occuring multiple-target inhibitor of NOS with IC50 value of 9.2 μM, BChE with IC50 value of 31.4 μM, a potent calcium antagonist on vascular smooth muscle. It is also a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 BuChE

IC50:31.4μmol NO Synthesis

IC50:9.2μmol
描述Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM^[3]. Imperatorin can activate RUNX2, COL1A1 and osteocalcin by promoting the Ser9 phosphorylation of GSK3β and entry of β-catenin into the nucleus. Intragastric administration of imperatorin promoted osteogenesis and inhibited osteoclast in vivoYan DY, Tang J, Chen L, Wang B, Weng S, Xie Z, Wu ZY, Shen Z, Bai B, Yang L. Imperatorin promotes osteogenesis and suppresses osteoclast by activating AKT/GSK3 β/β-catenin pathways. J Cell Mol Med. 2020 Feb;24(3):2330-2341|https://pubmed.ncbi.nlm.nih.gov/31883297Yan DY, Tang J, Chen L, Wang B, Weng S, Xie Z, Wu ZY, Shen Z, Bai B, Yang L. Imperatorin promotes osteogenesis and suppresses osteoclast by activating AKT/GSK3 β/β-catenin pathways. J Cell Mol Med. 2020 Feb;24(3):2330-2341|https://pubmed.ncbi.nlm.nih.gov/31883297. Imperatorin is a weak agonist of TRPV1, a channel implicated in detecting several noxious stimuli, exhibiting a 50% effective concentration (EC50) of 12.6 ± 3.2 μM^[4]. Imperatorin administered acutely at the doses of 5 and 10 mg/kg prior to the injection of scopolamine (1 mg/kg) improved memory acquisition and consolidation impaired by scopolamine. Furthermore, repeatable (7 days, twice daily) administration of the highest dose of imperatorin (10 mg/kg) significantly attenuated the effects of scopolamine on memory acquisition, whereas the doses of 5 and 10 mg/kg of this furanocoumarin were effective when memory consolidation was measured. Imperatorin, administered with scopolamine, increased antioxidant enzymes activity and decreased concentration of malondiamide, an indicator of lipid peroxidation level^[5]. Imperatorin inhibited HIF-1α (hypoxia-inducible factor-1) protein synthesis by downregulating the mTOR/p70S6K(ribosomal protein S6 kinase)/4E-BP1 (eIF4E binding protein-1) and MAPK pathways^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6999 mL
- 18.4993 mL
- 36.9987 mL
- 5 mM
- 0.7400 mL
- 3.6999 mL
- 7.3997 mL
- 10 mM
- 0.3700 mL
- 1.8499 mL
- 3.6999 mL

技术信息

CAS号

482-44-0

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H14O4

运输

蓝冰

分子量

270.28

别名

Ammidin;Marmelosin;Pentosalen;8-Isoamylenoxypsoralen;8-Isopentenyloxypsoralene;NSC 402949;欧前胡素

溶解度

DMSO	350.0 mg/mL (1295.0 mM)
Water	insoluble

动物实验配方

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靶点	Description	IC50
BuChE		IC50:31.4μmol
NO Synthesis		IC50:9.2μmol

Imperatorin/欧前胡素 Catalog No. CSN16369

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