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CAS No.: 509093-47-4

IRAK-1-4 Inhibitor I/IRAK1 / 4抑制剂I Catalog No. CSN18307

Synonyms: IRAK-1/4 Inhibitor I;IRAK-1/4 Inhibitor

IRAK-1-4 Inhibitor I is a IRAK-4 inhibitor with IC50 of 200 nM.

规格	价格	促销价格	库存	数量

400-920-2911

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4) is a serine/threonine kinase acting downstream of members of the Toll/IL-1 receptor (TIR) family which has been confirmed an indispensable activator for NF-κB and MAPK pathways. IRAK-1-4 inhibitor I is an IRAK-4 inhibitor with IC50 of 200 nM. IRAK-1/4 inhibitor treatment (50 μM, 2 h) in NCM460 cells reduced the LPS-induced increase in IL-8 response by 60% and Bcl10 by 73% respectively.
作用机制IRAK-1-4 Inhibitor I plays the role of IRAK-4 inhibitor by binding with acyl-2-aminobenzimidazole scaffold that represents a unique kinase binding motif.
动物研究
剂量
Mice: 2.12 mg/kg^[3] (i.p.); 35 mg/kg^[4] (intratumorally, i.t.)

给药途径
i.p., i.t.
参考文献

动物研究
剂量	Mice: 2.12 mg/kg^[3] (i.p.); 35 mg/kg^[4] (intratumorally, i.t.)
给药途径	i.p., i.t.

[1] Bhattacharyya S, Borthakur A, et al. Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2007 Aug;293(2):G429-37.
[2] Powers JP, Li S, et al. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5290 mL
- 12.6450 mL
- 25.2901 mL
- 5 mM
- 0.5058 mL
- 2.5290 mL
- 5.0580 mL
- 10 mM
- 0.2529 mL
- 1.2645 mL
- 2.5290 mL

技术信息

CAS号

509093-47-4

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H21N5O4

运输

蓝冰

分子量

395.41

别名

IRAK-1/4 Inhibitor I;IRAK-1/4 Inhibitor

溶解度

DMSO	15.0 mg/mL (37.9 mM) warming
Water	insoluble

动物实验配方

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IRAK-1-4 Inhibitor I/IRAK1 / 4抑制剂I Catalog No. CSN18307

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