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CAS No.: 27975-19-5

Isosteviol/异甜菊醇 Catalog No. CSN11232

Synonyms: (-)-Isosteviol;iso-Steviol;NSC-231875

Isosteviol, an antihyperglycemic agent, is a natural product isolated and purified from the herbs of Stevia rebaudiana with anti-hyperglycemic, anti-hypertensive, anti-tumor, anti-inflammatory, and antioxidant properties.

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400-920-2911

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技术信息

生物活性

描述Isosteviol is a derivative of stevioside, a constituent of Stevia rebaudiana. Isosteviol dose-dependently relaxed the vasopressin (10(-8) M)-induced vasoconstriction in isolated aortic rings with or without endothelium. Vasodilatation induced by isosteviol is related to the opening of SK(Ca) and K(ATP) channels^[3]. The increase of [Ca (2+)]i in A7r5 cells produced by vasopressin (1 micromol/L) or phenylephrine (1 micromol/L) was attenuated by isosteviol from 0.01 micromol/L to 10 micromol/L. Furthermore, the inhibitory action of isosteviol on [Ca (2+)]i was blocked when A7r5 cells co-treated with glibenclamide and apamin in conjunction with 4-aminopyridine were present^[4]. Isosteviol (1-100 micromol/l) inhibits angiotensin-II-induced DNA synthesis and endothelin-1 secretion^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1402 mL
- 15.7010 mL
- 31.4021 mL
- 5 mM
- 0.6280 mL
- 3.1402 mL
- 6.2804 mL
- 10 mM
- 0.3140 mL
- 1.5701 mL
- 3.1402 mL

技术信息

CAS号

27975-19-5

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H30O3

运输

蓝冰

分子量

318.45

别名

(-)-Isosteviol;iso-Steviol;NSC-231875;异甜菊醇

溶解度

DMSO	100.0 mg/mL (314.0 mM)

动物实验配方

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