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CAS No.: 686772-17-8

IWP-4 Catalog No. CSN22864

Synonyms: Inhibitor of Wnt Production-4

IWP 4 is a potent inhibitor of Wnt/β-catenin signaling with IC50 of 25 nM.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. IWP-4 is a small molecule Wnt inhibitor with an IC₅₀ of 25 nM. IWP-4 treatment resulted in a large percentage of cells expressing low amounts of cardiac myosin heavy chain and expression of early cardiac progenitor markers ISL1 and NKX2-5, thus indicating the production of large numbers of immature cardiomyocytes (~65,000/cm² or ~1.5 per input human embryonic stem cell (hESC)). In addition, IWP-4 induced expression of both atrial (MLC2a) and ventricular (MLC2v) forms. Mesenchymal precursor cells (MPCs) treated with IWP-4 express elevates levels of DKK1 (Dickkopf homolog 1) and GSK3β (glycogen synthase kinase 3 β) on day 21. IWP-4 also causes a significant down regulation of SPARC (secreted protein acidic and rich incysteine) and COL1A1 (Collagen 1A1).

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0136 mL
- 10.0680 mL
- 20.1359 mL
- 5 mM
- 0.4027 mL
- 2.0136 mL
- 4.0272 mL
- 10 mM
- 0.2014 mL
- 1.0068 mL
- 2.0136 mL

技术信息

CAS号

686772-17-8

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H20N4O3S3

运输

蓝冰

分子量

496.62

别名

Inhibitor of Wnt Production-4

溶解度

DMSO	insoluble
Water	insoluble

动物实验配方

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IWP-4 Catalog No. CSN22864

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