|3-((4-(吡啶-2-基)噻唑-2-基)氨基)苯酚|CsnPharm

CAS No.: 315702-75-1

KCC-07 Catalog No. CSN27212

KCC 07 is a MBD2 inhibitor.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述DNA methylation is a process by which methyl groups are added to cytosine or adenine. DNA methylation can change the activity of the DNA molecule without changing the sequence. Methylation of 5-methylcytosine (5mC) is widespread in both eukaryotes and prokaryotes, and it is a very important epigenetic modification event, which can regulate gene activity and influence a number of key processes such as genomic imprinting, cell differentiation, transcriptional regulation, and chromatin remodeling^[2]. 5-Methylcytosine binding domain (MBD) family proteins are essential readers of DNA methylation^[3].Proteins containing a methyl-CpG-binding domain (MBD) bind 5mC and convert the methylation pattern information into appropriate functional cellular states. The correct readout of epigenetic marks is of particular importance in the nervous system where abnormal expression or compromised MBD protein function, can lead to disease and developmental disorders^[4]. The methylcytosine-binding domain 2 (MBD2) protein recruits the nucleosome remodeling and deacetylase complex (NuRD) to methylated DNA to modify chromatin and regulate transcription. Importantly, MBD2 functions within CpG islands that contain 100s to 1000s of potential binding sites. Since NuRD physically rearranges nucleosomes, the dynamic mobility of this complex is directly related to function^[5]. KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. In vitro, KCC-07 treatment Medulloblastomas (MB) cells clearly inhibited MB cell growth, consistent with induction of anti-proliferative BAI1/p53/p21 signaling^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7130 mL
- 18.5652 mL
- 37.1303 mL
- 5 mM
- 0.7426 mL
- 3.7130 mL
- 7.4261 mL
- 10 mM
- 0.3713 mL
- 1.8565 mL
- 3.7130 mL

技术信息

CAS号	315702-75-1	储存条件	粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C14H11N3OS	运输	蓝冰
分子量	269.32	别名

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

KCC-07 Catalog No. CSN27212

靶点选择性

请登录您的专属账户

确认信息