|N-(2-(((3-(4-氯苯基)烯丙基)(甲基)氨基)甲基)苯基)-4-甲氧基苯磺酰胺磷酸盐|CsnPharm

CAS No.: 1135280-28-2

KN-92 phosphate Catalog No. CSN16913

Synonyms: KN-92

KN-92 phosphate is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).

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生物活性

实验方案

技术信息

生物活性

描述KN-92 phosphate is an inactive derivative of KN-93, without CaM kinase inhibitory activity^[3]. Incubation of 10 micromol/L KN-93 induced the cell growth reduction in a time-dependent manner from 78.27% at 8 h to 11.48% at 48 h. However, KN-92, an inactive derivative of KN-93, did not inhibit cell proliferation effectively^[4]. Inhibition of Ca2+/calmodulin kinase (KN-63, KN-92; 5 microM) reduced Cl--conductance in 50% of the cells investigated without affecting [Ca2+]i^[5]. The CaMKII inhibitor, KN-93 (N-[2-(N-(4-Chlorocinnamyl)-N-methylaminomethyl)phenyl]-N-[2-hydroxyethyl]-4-methoxybenzenesulfonamide), but not the inactive isomer, KN-92 (2-[N-(4-Methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine, phosphate), blocked clozapine's augmenting effect on NMDA-evoked responses in pyramidal cells of the rat mPFC. KN-93 also inhibited the facilitatory effect of clozapine on electrically evoked responses in the pyramidal cells, while KN-92 did not show any effect^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8019 mL
- 9.0093 mL
- 18.0187 mL
- 5 mM
- 0.3604 mL
- 1.8019 mL
- 3.6037 mL
- 10 mM
- 0.1802 mL
- 0.9009 mL
- 1.8019 mL

技术信息

CAS号

1135280-28-2

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H28ClN2O7PS

运输

蓝冰

分子量

554.98

别名

KN-92

溶解度

DMSO	98.0 mg/mL (176.6 mM)
Water	Insoluble
Ethanol	10.0 mg/mL (18.0 mM)

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