|昆布多糖|CsnPharm

CAS No.: 9008-22-4

Synonyms: Iodus 40;beta-1,3-Glucan;昆布多糖

Laminarin, a natural polysaccharide isolated and purified from Laminaria digitata with anticancer activity.

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400-920-2911

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生物活性

描述Laminarin, a natural polysaccharide isolated and purified from Laminaria digitata with anticancer activity. The Pp IX-loaded HLDM (Hematin-Laminarin-Dithiodipropionic Acid-MGK) micelles could induce remarkable anti-tumor effect. A promising laminarin-based nanomedicine platform acts as a new drug delivery system to enhance the uptake, accumulation, and PDT (photodynamic therapy) efficacy of Pp IX (protoporphyrin IX) in vitro and in vivo^[2]. Laminarin decreases cell growth and cell cycle progression of OC (Ovarian cancer) cells through the regulation of intracellular signaling. Moreover, laminarin induced cell death through DNA fragmentation, reactive oxygen species generation, induction of apoptotic signals and endoplasmic reticulum (ER) stress, regulation of calcium levels, and alteration of the ER-mitochondria axis. Laminarin was not cytotoxic in a zebrafish model, while in a zebrafish xenograft model, it inhibited OC cell growth^[3]. Following the treatment of LoVo cells with laminarin for 24 h, the expression levels of DR4, DR5, TRAIL, FADD, Bid, tBid and Bax were observed to be upregulated, whereas the expression levels of pro-caspase-8, pro-caspase-3 and Bcl-2 were downregulated^[4]. The combination treatment of laminarin and ovalbumin inhibited B16-ovallbumin melanoma tumor growth and its liver metastasis by antigen-specific immune activation, including cytotoxic T lymphocyte activation and interferon-γ production^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02502552	-	-	Completed	-	France ... more >> CHU Saint-Etienne Saint-Etienne, France, 42055 Collapse <<
NCT02682017	Antioxidant Status, Inflammati... more >>on Collapse <<	Not Applicable	Completed	-	United Kingdom ... more >> Human Intervention Studies Unit, Ulster University Coleraine, Co.Londonderry, United Kingdom, BT52 1SA Collapse <<

实验方案

技术信息

CAS号	9008-22-4	储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式		运输	蓝冰
分子量	N/A	别名	Iodus 40;beta-1,3-Glucan;昆布多糖

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