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CAS No.: 14769-73-4

Levamisole/左旋咪唑 Catalog No. CSN25642

Synonyms: Levamisole;L-Tetramisole;Levamisol

levamisole is a drug with immunomodulatory effects. Levamisole shows benefit on patients with recurrent Herpes infection. Levamisole is a competitive inhibitor of alkaline phosphatase.

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技术信息

生物活性

描述Levamisole is an anthelmintic agent with immunomodulatory effects^[1]. Treatment of human dendritic cells with 1 μM levamisole significantly promoted the secretion of IL-12 p40 and IL-10 secretion compared to the control group. Levamisole at 1 μM also further enhanced lipopolysaccharide (10 ng/mL)-induced production of IL-12 p40 and IL-10 in human dendritic cells. Levamisole-treated dendritic enhanced T cell activation towards type 1 cytokine balance. The NF-κB and JNK pathways were involved in levamisole-induced secretion of IL-12 p40 in dendritic cells^[2]. In mice infected with 1,000 infective T canis larvae, subcutaneous administration of levamisole hydrochloride at a dose of 12 mg/kg/day from days 15 to 28 of infection decreased the infection in all organs^[3].
作用机制Levamisole exerts its immunomodulatory effects through cholinergic activity on T lymphocytes, resulting in an increase in the level of cyclic guanosine monophosphate in lymphocytes^[1].
参考文献

[1] Scheinfeld N, Rosenberg JD, Weinberg JM. Levamisole in dermatology : a review. Am J Clin Dermatol. 2004;5(2):97-104. doi: 10.2165/00128071-200405020-00004
[2] Chen LY, Lin YL, Chiang BL. Levamisole enhances immune response by affecting the activation and maturation of human monocyte-derived dendritic cells. Clin Exp Immunol. 2008 Jan;151(1):174-81. doi: 10.1111/j.1365-2249.2007.03541.x
[3] Carrillo M, Barriga OO. Anthelmintic effect of levamisole hydrochloride or ivermectin on tissue toxocariasis of mice. Am J Vet Res. 1987 Feb;48(2):281-3

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.8950 mL
- 24.4748 mL
- 48.9497 mL
- 5 mM
- 0.9790 mL
- 4.8950 mL
- 9.7899 mL
- 10 mM
- 0.4895 mL
- 2.4475 mL
- 4.8950 mL

技术信息

CAS号	14769-73-4	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C11H12N2S	运输	蓝冰
分子量	204.29	别名	Levamisole;L-Tetramisole;Levamisol;LMS;Ergamisol;Decaris;Levotetramisole;Solaskil;Ketrax;左旋咪唑碱;(-)-Tetramisole

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