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CAS No.: 28831-65-4

Lithospermic acid/紫草酸 Catalog No. CSN19879

Synonyms: (+)-Lithospermic acid;Lithospermic Acid;Lithospermic Acid-A

Lithospermic acid is a natural product isolated and purified from the roots of Lithospermum ruderale with anti-HIV, anti-gonadotrophic and anti-thyroidal effects, and is a cardiotonic agent.

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生物活性

描述Lithospermic acid is a natural product isolated and purified from the roots of Lithospermum ruderale with anti-HIV, anti-gonadotrophic and anti-thyroidal effects, and is a cardiotonic agent^[3]. LSA (Lithospermic Acid) inhibited the formation of uric acid and superoxide radicals significantly with an IC50 5.2 and 1.08 mg/ml, respectively, and exhibited competitive inhibition. LSA scavenged superoxide radicals directly in the system beta-NADH/PMS and inhibited the production of superoxide in human neutrophils stimulated by PMA and fMLP. LSA also have hypouricemic activity on oxonate-pretreated rats in vivo and have anti-inflammatory effects in a model of gouty arthritis^[4]. Lithospermic acid significantly attenuated the CCl4-induced oxidative damage in a concentration-dependent manner. Pretreatment of mice with lithospermic acid for six days significantly reduced CCl4-induced hepatic oxidative damage, serum AST (aspartate transaminase) and ALT(alanine transaminase). The pretreatment also increased SOD (superoxide dismutase) and CAT (catalase)^[5]. Lithospermic acid possesses specific inhibitory effect on caspase 3^[6]. Lithospermic acid attenuates mesenteric ischemia reperfusion injury in rat intestines by increasing tissue SOD and GPx (glutathione peroxidase) activities and decreasing MDA and MPO (myeloperoxidase) levels. Lithospermic acid also improves morphological alterations which occurred after periods of reperfusion^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8571 mL
- 9.2857 mL
- 18.5715 mL
- 5 mM
- 0.3714 mL
- 1.8571 mL
- 3.7143 mL
- 10 mM
- 0.1857 mL
- 0.9286 mL
- 1.8571 mL

技术信息

CAS号	28831-65-4	储存条件	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C27H22O12	运输	蓝冰
分子量	538.46	别名	(+)-Lithospermic acid;Lithospermic Acid;Lithospermic Acid-A;紫草酸

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