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CAS No.: 1254473-64-7
Synonyms: LY2874455
LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM.
规格 | 价格 | 促销价格 | 库存 | 数量 |
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生物活性
靶点 | FGFR1 IC50:2.8nM | FGFR2 IC50:2.6nM | FGFR3 IC50:6.4nM | FGFR4 IC50:6nM | VEGFR2 IC50:7nM |
动物研究 | |
剂量 | Rat[2] (p.o.): 1 mg/kg - 10 mg/kg |
给药途径 | p.o. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT03125239 | Relapsed Adult Acute Myeloid L... more >>eukemia Refractory Adult Acute Myeloid Leukemia Collapse << | Phase 1 | Recruiting | June 1, 2020 | United States, Massachusetts ... more >> Brigham and Women's Hospital Enrolling by invitation Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Jacqueline S Garcia, MD 617-632-6349 jacqueline_garcia@dfci.harvard.edu Principal Investigator: Jacqueline S Garcia, MD Collapse << |
NCT01212107 | Advanced Cancer | Phase 1 | Completed | - | Australia, Victoria ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. East Melbourne, Victoria, Australia, 3002 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Parkville, Victoria, Australia, 3050 Korea, Republic of For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Seoul, Korea, Republic of, 110-744 Collapse << |
实验方案
技术信息
CAS号 | 1254473-64-7 | 储存条件 |
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分子式 | C21H19Cl2N5O2 | 运输 | 蓝冰 | |||||||||||||
分子量 | 444.31 | 别名 | LY2874455 | |||||||||||||
溶解度 |
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动物实验配方 |
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