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CAS No.: 19908-48-6

Maackiain/高丽槐素 Catalog No. CSN19943

Synonyms: DL-Maackiain;马卡因

DL-Maackiain is extracted from the flowers of maackia amurensis rupr.et maxim. and can induce apoptosis and growth suppression.

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实验方案

技术信息

生物活性

描述DL-Maackiain (Maackiain) is extracted from the flowers of maackia amurensis rupr.et maxim. and can induce apoptosis and growth suppression. Maackiain (DL-Maackiain) is a larvicidal agent against Aedes aegypti mosquito.xp Parasitol with a LD50 of 21.95 µg/mL^[3]. Extent of induction of apoptosis by maackiain was larger than that by trifolirhizin in human leukemia HL-60 cells^[4]. MK (Maackiain) significantly reduced dopaminergic neuron damage in 6-hydroxydopamine (6-OHDA)-exposed worms of the BZ555 strain, with corresponding improvements in food-sensing behavior and life-span. In transgenic worms of strain NL5901 treated with 0.25 mM MK, the accumulation of α-synuclein was diminished by 27% compared with that in untreated worms. Moreover, in worms and the SH-SY5Y cell line, we confirmed that the mechanism of MK-mediated protection against PD pathology may include blocking apoptosis, enhancing the ubiquitin-proteasome system, and augmenting autophagy by increasing PINK1/parkin expression^[5]. Maackiain could restrain receptor activator of nuclear factor-κB ligand (RANKL)-stimulated osteoclast formation and hydroxyapatite resorption dose-dependently, and interrupt the structures of F-actin belts in the mature osteoclasts. It also repressed the expressions of osteoclast-specific genes and proteins. Furthermore, Maackiain could inhibit RANKL-stimulated NF-κB and calcium signalling pathways, and dampen Nuclear factor of activated T cell cytoplasmic 1 activity, protein expression and translocation into the nucleus^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5179 mL
- 17.5893 mL
- 35.1786 mL
- 5 mM
- 0.7036 mL
- 3.5179 mL
- 7.0357 mL
- 10 mM
- 0.3518 mL
- 1.7589 mL
- 3.5179 mL

技术信息

CAS号

19908-48-6

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H12O5

运输

蓝冰

分子量

284.26

别名

DL-Maackiain;马卡因

溶解度

DMSO	56.0 mg/mL (197.0 mM)

动物实验配方

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