生物活性

• 描述Mafenide hydrochloride is a sulfonamide-type medication used as an antibiotic. Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns^[3]. The activity of 2.5% mafenide hydrochloride solution was equal to that of 4% mafenide HCl and could be used clinically with significant savings and perhaps, fewer side effects^[4]. Survival time was lengthened by the application of some topical antibacterial agents, but actual recovery was achieved only with topical mafenide hydrochloride solution aqueous spray, which resulted in negative clostridium. Mafenide hydrochloride solution spray has been used successfully in treatment of patients with severe by contaminated wounds and deep burns^[1].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01654094	Burns Skin Bu... more >>rn Requiring Skin Graft Collapse <<	Not Applicable	Completed	-	United States, Florida ... more >> Shands at University of Florida Gainesville, Florida, United States, 32610 United States, North Carolina University of North Carolina, Chapel Hill Chapel Hill, North Carolina, United States, 27599 Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 United States, Tennessee University of Tennessee Firefighter's Regional Burn Center Memphis, Tennessee, United States, 38103 Collapse <<
  NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... more >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD    502-852-1148    jarami01@louisville.edu    Contact: David Seligson, MD    502-852-0923    d0seli01@louisville.edu    Sub-Investigator: Forest Arnold, DO          Sub-Investigator: Timothy Wiemkwn, PhD          Sub-Investigator: Robert Kelley, PhD          Sub-Investigator: James Summersgill, PhD          Sub-Investigator: Ruth Carrico, PhD          Sub-Investigator: Julie Harting, PharmD          Sub-Investigator: Paula Peyrani, MD          Principal Investigator: David Seligson, MD          Sub-Investigator: Craig Roberts, MD          Principal Investigator: Julio Ramirez, MD Collapse <<
  NCT00586729	Burns	Not Applicable	Completed	-	United States, Arizona ... more >> Maricopa Integrated Health System Phoenix, Arizona, United States, 85008 Collapse <<

• 更多
• 参考文献

• [1] Mendelson JA. Topical mafenide hydrochloride aqueous spray in initial management of massive contaminated wounds with devitalized tissue. Prehosp Disaster Med. 2001;16(3):172–174

  [2] Mendelson JA. The management of burns under conditions of limited resources using topical aqueous sulfamylon (mafenide) hydrochloride spray. J Burn Care Rehabil. 1997 May-Jun;18(3):238-44.

  [3] Haik J, Ashkenazy O, Sinai S, et al. Burn care standards in Israel: lack of consensus. Burns. 2005;31(7):845–849

  [4] Holder IA. Wet disc testing of mafenide hydrochloride, chlorhexidine gluconate, and triple antibiotic solution against bacteria isolated from burn wounds. J Burn Care Rehabil. 1990;11(4):301–304