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CAS No.: 32383-76-9

Medicarpin Catalog No. CSN14398

Synonyms: Demethylhomopterocarpin;NSC-350085

Medicarpin, a natural product isolated and purified from the herb of Hedysarum polybotrys Hand. Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways.

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技术信息

生物活性

描述Medicarpin, a natural product isolated and purified from the herb of Hedysarum polybotrys Hand. -Mazz., sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the upregulation of DR5 through activation of the ROS-JNK-CHOP pathway, and stimulates osteoblast differentiation likely via ERβ, promotes achievement of peak bone mass, and is devoid of uterine estrogenicity. In addition, given its excellent oral bioavailability, Medicarpin can be potential osteogenic agent.
参考文献

[1] Ghelich S, Zarinkamar F, et al. Effect of lead treatment on medicarpin accumulation and on the gene expression of key enzymes involved in medicarpin biosynthesis in Medicago sativa L. Environ Sci Pollut Res Int. 2014 Dec;21(24):14091-8.
[2] Trivedi R, Maurya R, Mishra DP. Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway. Cell Death Dis. 2014 Oct 16;5:e1465.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6999 mL
- 18.4993 mL
- 36.9987 mL
- 5 mM
- 0.7400 mL
- 3.6999 mL
- 7.3997 mL
- 10 mM
- 0.3700 mL
- 1.8499 mL
- 3.6999 mL

技术信息

CAS号	32383-76-9	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C16H14O4	运输	蓝冰
分子量	270.28	别名	Demethylhomopterocarpin;NSC-350085

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