|Melittin游离|CsnPharm

CAS No.: 20449-79-0

Synonyms: MLT;Forapin;Forapine

Melittin can bind calmodulin in a Ca²⁺-dependent manner and inhibit Na⁺-K⁺-ATPase that plays a vital role in Epilepsy treatment.

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400-920-2911

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描述Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not increase activity of the high molecular weight PLA2^[1]. Melittin is a cytotoxic peptide from bee venom. Melittin exhibits toxicity against both A2780CR and A2780 cells, with IC50 values of 4.5 and 6.8 μg/mL, respectively. Melittin has natural anti-bacterial, anti-viral, and anti-inflammatory properties. Melittin, an amphipathic haemolytic peptide, exerts its potential anticancer effects include inhibition of cell proliferation, induction of apoptosis, and direct necrosis. The changes induced by melittin in the cisplatin-sensitive cells led mostly to reduced levels of amino acids in the proline/glutamine/arginine pathway, as well as to decreased levels of carnitines, polyamines, adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NAD+)^[2]. Melittin is the major pain-producing substance of bee venom, by which peripheral persistent pain and hyperalgesia (or allodynia), primary nociceptive neuronal sensitization, and CNS synaptic plasticity (or metaplasticity) can be readily induced and the molecular and cellular mechanisms underlying naturally-occurring venomous biotoxins can be experimentally unraveled^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02535416	Healthy	Phase 1	Completed	-	Australia, Queensland ... more >> QPharm, Pty Limited, Royal Brisbane Hospital Herston, Queensland, Australia, 4029 Collapse <<
NCT02363946	Alpha-1 Antitrypsin Deficiency	Phase 1	Terminated(Company decision to... more >> terminate the trial) Collapse <<	-	Australia, Victoria ... more >> Nucleus Network Ltd Melbourne, Victoria, Australia, 3004 Germany Universitatsklinikum des Saarlandes Homburg, Germany Netherlands Leiden University Medical Center Leiden, Netherlands, 2333ZA United Kingdom Queen Elizabeth Hospital Edgbaston, Birmingham, United Kingdom, B15 2WB Collapse <<
NCT02363946	-	-	Terminated(Company decision to... more >> terminate the trial) Collapse <<	-	-

实验方案

技术信息

CAS号	20449-79-0	储存条件	粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C131H229N39O31	运输	蓝冰
分子量	2846.46	别名	MLT;Forapin;Forapine;蜂毒肽

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