生物活性

• 描述Methocarbamol is a commonly used, centrally acting muscle relaxant and has not been linked to instances of liver injury^[3]. Methocarbamol is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. Absorption and elimination of methocarbamol is similar between normal subjects and patients undergoing maintenance haemodialysis^[4]. Patients who were treated with methocarbamol showed a significant decrease in the frequency and duration of cramps. Also, the pain score improved significantly. Methocarbamol seems to be a promising safe and well-tolerated medication, and plays a role in the treatment of muscle cramps in patients with liver cirrhosis^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00770497	Inflammation ... more >>Hypertension Collapse <<	Phase 2	Completed	-	Germany ... more >> Deggingen, Baden-Württemberg, Germany Rottweil, Baden-Württemberg, Germany Spaichingen, Baden-Württemberg, Germany Weilersbach, Bayern, Germany Hannover, Niedersachsen, Germany Essen, Nordrhein-Westfalen, Germany Köln, Nordrhein-Westfalen, Germany Werne, Nordrhein-Westfalen, Germany Mainz, Rheinland-Pfalz, Germany Schauenburg, Rheinland-Pfalz, Germany Dresden, Sachsen, Germany Blankenhain, Thüringen, Germany Berlin, Germany Collapse <<
  NCT02707094	Chronic Low Back Pain	Not Applicable	Completed	-	United States, Texas ... more >> Brooke Army Medical Center Fort Sam Houston, Texas, United States, 78234 Collapse <<
  NCT02669875	Liver Cirrhosis ... more >> Hypertension, Portal Collapse <<	Phase 2	Completed	-	United Kingdom ... more >> Liver Unit, Royal Infirmary of Edinburgh Edinburgh, United Kingdom, EH164TJ Collapse <<

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• 参考文献

• [1] Rumpler MJ, Colahan P, Sams RA. The pharmacokinetics of methocarbamol and guaifenesin after single intravenous and multiple-dose oral administration of methocarbamol in the horse. J Vet Pharmacol Ther. 2014 Feb;37(1):25-34.

  [2] Kuo K, Odunayo A. Adjunctive therapy with intravenous lipid emulsion and methocarbamol for permethrin toxicity in 2 cats. J Vet Emerg Crit Care (San Antonio). 2013 Jul-Aug;23(4):436-41.

  [3] Methocarbamol. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; January 30, 2017

  [4] Sica DA, Comstock TJ, Davis J, et al. Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol. 1990;39(2):193-194

  [5] Abd-Elsalam S, Arafa M, Elkadeem M, et al. Randomized-controlled trial of methocarbamol as a novel treatment for muscle cramps in cirrhotic patients. Eur J Gastroenterol Hepatol. 2019;31(4):499-502

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